Acute effects of bilateral subthalamic stimulation on decision-making in Parkinson's disease

被引：31

作者：

Oyama, Genko ^{[1
]}

Shimo, Yasushi ^{[1
]}

Natori, Shihoko ^{[1
]}

Nakajima, Madoka ^{[2
]}

Ishii, Hisato ^{[2
]}

Arai, Hajime ^{[2
]}

Hattori, Nobutaka ^{[1
]}

机构：

[1] Juntendo Univ, Sch Med, Dept Neurol, Bunkyo Ku, Tokyo 1138421, Japan

[2] Juntendo Univ, Sch Med, Dept Neurosurg, Tokyo 1138421, Japan

来源：

PARKINSONISM & RELATED DISORDERS | 2011年 / 17卷 / 03期

关键词：

Subthalamic nucleus; Deep brain stimulation; Parkinson's disease; DEEP BRAIN-STIMULATION; IOWA GAMBLING TASK; NUCLEUS STIMULATION; BASAL GANGLIA; MEDICATION; ANATOMY; APATHY; PET;

D O I：

10.1016/j.parkreldis.2010.12.004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Pathological gambling can develop in Parkinson's disease (PD), and impairment of decision-making may play an important role in the mechanism. To assess acute effects of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on decision-making, patients with PD who were eligible for STN-DBS were evaluated using the Iowa Gambling Task (IGT). Methods: The study participants were 16 patients with PD who underwent bilateral STN-DBS, and 16 age-matched control patients with PD. The participants performed the IGT pre-operatively and 2-4 weeks post-operatively with on- and off-stimulation. Participants' one hundred card selections were divided into five blocks of 20 cards each. Results: The total IGT score was not significantly different before surgery, on-stimulation or off-stimulation, but DBS patients tended to perform worse in the on-DBS session compared to off-DBS session (P = 0.019) only in the last block of the task. The IGT score did not correlate with levodopa equivalent dose or performance on the measures of executive function, but did correlate with self-reported depression symptoms, and active contact of stimulation. Conclusion: Bilateral STN-DBS may affect decision-making in acute post-operative stage. (C) 2010 Published by Elsevier Ltd.

引用

页码：189 / 193

页数：5

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