Current Developments of N-Heterocyclic Carbene Au(I)/Au(III) Complexes toward Cancer Treatment

被引：27
|
作者：
Tialiou, Alexia [1 ,2 ]
Chin, Jiamin [3 ]
Keppler, Bernhard K. [1 ,4 ,5 ]
Reithofer, Michael R. [1 ]
机构：
[1] Univ Vienna, Fac Chem, Inst Inorgan Chem, Wahringer Str 42, A-1090 Vienna, Austria
[2] Univ Vienna, Vienna Doctoral Sch Chem DoSChem, Wahringer Str 42, A-1090 Vienna, Austria
[3] Univ Vienna, Inst Inorgan Chem Funct Mat, Fac Chem, Wahringer Str 42, A-1090 Vienna, Austria
[4] Univ Vienna, Res Cluster Translat Canc Therapy Res, Wahringer Str 42, A-1090 Vienna, Austria
[5] Med Univ Vienna, Wahringer Str 42, A-1090 Vienna, Austria
来源：
BIOMEDICINES | 2022年 / 10卷 / 06期
基金：
奥地利科学基金会;
关键词：
cancer; gold complexes; N-heterocyclic carbenes; NHC; DNA; G-quadruplex; G-QUADRUPLEX; GOLD(III) COMPLEXES; HISTORY LANDMARKS; METAL-COMPLEXES; GOLD COMPOUNDS; DNA; CHEMISTRY; NHC; LIGANDS; BINDING;
D O I：
10.3390/biomedicines10061417
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Since their first discovery, N-heterocyclic carbenes have had a significant impact on organometallic chemistry. Due to their nature as strong sigma-donor and pi-acceptor ligands, they are exceptionally well suited to stabilize Au(I) and Au(III) complexes in biological environments. Over the last decade, the development of rationally designed NHCAu(I/III) complexes to specifically target DNA has led to a new "gold rush" in bioinorganic chemistry. This review aims to summarize the latest advances of NHCAu(I/III) complexes that are able to interact with DNA. Furthermore, the latest advancements on acyclic diamino carbene gold complexes with anticancer activity are presented as these typically overlooked NHC alternatives offer great additional design possibilities in the toolbox of carbene-stabilized gold complexes for targeted therapy.
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页数：26
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