Current Developments of N-Heterocyclic Carbene Au(I)/Au(III) Complexes toward Cancer Treatment

被引：27

作者：

Tialiou, Alexia ^{[1
,2
]}

Chin, Jiamin ^{[3
]}

Keppler, Bernhard K. ^{[1
,4
,5
]}

Reithofer, Michael R. ^{[1
]}

机构：

[1] Univ Vienna, Fac Chem, Inst Inorgan Chem, Wahringer Str 42, A-1090 Vienna, Austria

[2] Univ Vienna, Vienna Doctoral Sch Chem DoSChem, Wahringer Str 42, A-1090 Vienna, Austria

[3] Univ Vienna, Inst Inorgan Chem Funct Mat, Fac Chem, Wahringer Str 42, A-1090 Vienna, Austria

[4] Univ Vienna, Res Cluster Translat Canc Therapy Res, Wahringer Str 42, A-1090 Vienna, Austria

[5] Med Univ Vienna, Wahringer Str 42, A-1090 Vienna, Austria

来源：

BIOMEDICINES | 2022年 / 10卷 / 06期

基金：

奥地利科学基金会;

关键词：

cancer; gold complexes; N-heterocyclic carbenes; NHC; DNA; G-quadruplex; G-QUADRUPLEX; GOLD(III) COMPLEXES; HISTORY LANDMARKS; METAL-COMPLEXES; GOLD COMPOUNDS; DNA; CHEMISTRY; NHC; LIGANDS; BINDING;

D O I：

10.3390/biomedicines10061417

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Since their first discovery, N-heterocyclic carbenes have had a significant impact on organometallic chemistry. Due to their nature as strong sigma-donor and pi-acceptor ligands, they are exceptionally well suited to stabilize Au(I) and Au(III) complexes in biological environments. Over the last decade, the development of rationally designed NHCAu(I/III) complexes to specifically target DNA has led to a new "gold rush" in bioinorganic chemistry. This review aims to summarize the latest advances of NHCAu(I/III) complexes that are able to interact with DNA. Furthermore, the latest advancements on acyclic diamino carbene gold complexes with anticancer activity are presented as these typically overlooked NHC alternatives offer great additional design possibilities in the toolbox of carbene-stabilized gold complexes for targeted therapy.

引用

页数：26

共 154 条

[31] A History of Cancer Chemotherapy
DeVita, Vincent T., Jr.
Chu, Edward
[J]. CANCER RESEARCH, 2008, 68 (21) : 8643 - 8653
[32] Paradigms for computational nucleic acid design
Dirks, RM
Lin, M
Winfree, E
Pierce, NA
[J]. NUCLEIC ACIDS RESEARCH, 2004, 32 (04) : 1392 - 1403
[33] Catalytically Active Gold Nanomaterials Stabilized by N-heterocyclic Carbenes
Eisen, Constantin
Chin, Jia Min
Reithofer, Michael R.
[J]. CHEMISTRY-AN ASIAN JOURNAL, 2021, 16 (20) : 3026 - 3037
[34] Chrysotherapy: a synoptic review
Eisler, R
[J]. INFLAMMATION RESEARCH, 2003, 52 (12) : 487 - 501
[35] SYNCHROTRON X-RAY STUDIES OF METAL-BASED DRUGS AND METABOLITES
ELDER, RC
EIDSNESS, MK
[J]. CHEMICAL REVIEWS, 1987, 87 (05) : 1027 - 1046
[36] A brief history of cancer: Age-old milestones underlying our current knowledge database
Faguet, Guy B.
[J]. INTERNATIONAL JOURNAL OF CANCER, 2015, 136 (09) : 2022 - 2036
[37] Versatile synthesis of cationic N-heterocyclic carbene-gold(I) complexes containing a second ancillary ligand. Design of heterobimetallic ruthenium-gold anticancer agents
Fernandez-Gallardo, Jacob
Elie, Benelita T.
Sanau, Mercedes
Contel, Maria
[J]. CHEMICAL COMMUNICATIONS, 2016, 52 (15) : 3155 - 3158
[38] Fricker S.P., 1996, Gols Bulletin, V29, P53, DOI DOI 10.1007/BF03215464
[39] Cysteine proteases as targets for metal-based drugs
Fricker, Simon P.
[J]. METALLOMICS, 2010, 2 (06) : 366 - 377
[40] Cyclometalated Gold(III) Complexes Containing N-Heterocyclic Carbene Ligands Engage Multiple Anti-Cancer Molecular Targets
Fung, Sin Ki
Zou, Taotao
Cao, Bei
Lee, Pui-Yan
Fung, Yi Man Eva
Hu, Di
Lok, Chun-Nam
Che, Chi-Ming
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2017, 56 (14) : 3892 - 3896

← 1 2 3 4 5 6 7 8 9 10 →