Comparison of Subregional Breast Density with Whole Breast Density

被引：0

作者：

Malkov, Serghei ^{[1
]}

Ma, Lin ^{[2
,3
,4
]}

Kerlikowske, Karla ^{[2
,3
,4
]}

Wang, Jeff ^{[1
]}

Cummings, Steve ^{[2
,3
,4
,5
]}

Shepherd, John ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Radiol & Bioimaging, 1635 Divisadero St,Suite 525, San Francisco, CA 94115 USA

[2] Univ Calif San Francisco, Dept Med, San Francisco, CA USA

[3] Univ Calif San Francisco, Dept Epidemiol, San Francisco, CA USA

[4] Univ Calif San Francisco, Dept Biostat, San Francisco, CA USA

[5] San Francisco Coordinat Ctr, California Pacific Med Ctr, San Francisco, CA USA

来源：

DIGITAL MAMMOGRAPHY | 2010年 / 6136卷

关键词：

mammographic density; quantitative mammography; RISK;

D O I：

暂无

中图分类号：

TP301 [理论、方法];

学科分类号：

081202 ;

摘要：

The purpose of this paper is to compare subregional breast density and whole breast density and their association with breast cancer risk. The film mammograms of 278 cases and 834 age and ethnicity-matched controls were digitized and analyzed using single-energy x-ray absorptiometry (SXA). The subregion was a 3-cm diameter circle centered in the breast. The whole and subregional densities are found to be highly correlated (r(2)=0.7). The 4:1 quartile odds ratio after controlling for other significant risk factors (age. BMI, family history and age at first live birth) was 3.6 (95 CI 2.1-5.4) and the 2.4 (95 CI 1.5-3.7) for the whole and subregional breast density, respectively. Further studies are underway to optimize the placement of the ROI and combined multiple regions.

引用

页码：402 / +

页数：3

共 9 条

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