Smad-mediated miRNA processing A critical role for a conserved RNA sequence

被引：22

作者：

Davis-Dusenbery, Brandi N. ^{[1
]}

Hata, Akiko ^{[1
,2
]}

机构：

[1] Tufts Univ, Sch Med, Mol Cardiol Res Inst, Tufts Med Ctr, Boston, MA 02111 USA

[2] Tufts Univ, Sch Med, Dept Biochem, Boston, MA 02111 USA

来源：

RNA BIOLOGY | 2011年 / 8卷 / 01期

关键词：

microRNA; miRNA; TGF beta; BMP; smads; biogenesis; drosha; processing; MICRORNA MATURATION; POSTTRANSCRIPTIONAL REGULATION; TRANSCRIPTION FACTORS; DROSHA-DGCR8; COMPLEX; PROTEINS; RECOGNITION; BIOGENESIS; RECEPTOR; BINDING; P68;

D O I：

10.4161/rna.8.1.14299

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

microRNAs (miRNAs) are short, 21-24 nucleotide (nt), non-coding RNAs that post-transcriptionally regulate the expression of messenger RNAs (mRNAs). Through the regulation of their cognate mRNAs, miRNAs control diverse aspects of biology, including development, cellular differentiation, proliferation, metabolism and death. Thus, miRNAs play a critical role in the determination of normal cellular physiology and misexpression of miRNAs leads to pathological responses. Understanding the mechanisms that control miRNA expression is an important step forward as novel functions of miRNAs continue to be uncovered. In addition to transcriptional regulation, multiple pathways of post-transcriptional modulation of miRNA expression have been uncovered. In this review we discuss the role of the Smads in the regulation of miRNA processing in response to Transforming Growth Factor beta stimulation.

引用

页码：71 / 76

页数：6

共 35 条

[1] MicroRNAs: Target Recognition and Regulatory Functions [J].

Bartel, David P. .

CELL, 2009, 136 (02) :215-233

[2] Argonautes and company: Sailing against the wind [J].

Bhattacharyya, Suvendra N. ;

Filipowicz, Witold .

CELL, 2007, 128 (06) :1027-1028

[3] Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs [J].

Cai, XZ ;

Hagedorn, CH ;

Cullen, BR .

RNA, 2004, 10 (12) :1957-1966

[4] The RNA helicase p68 is a novel androgen receptor coactivator involved in splicing and is overexpressed in prostate cancer [J].

Clark, Emma L. ;

Coulson, Anne ;

Dalgliesh, Caroline ;

Rajan, Prabhakar ;

Nicol, Samantha M. ;

Fleming, Stewart ;

Heer, Rakesh ;

Gaughan, Luke ;

Leung, Hing Y. ;

Elliott, David J. ;

Fuller-Pace, Frances V. ;

Robson, Craig N. .

CANCER RESEARCH, 2008, 68 (19) :7938-7946

[5] SMAD proteins control DROSHA-mediated microRNA maturation [J].

Davis, Brandi N. ;

Hilyard, Aaron C. ;

Lagna, Giorgio ;

Hata, Akiko .

NATURE, 2008, 454 (7200) :56-U2

[6] Smad Proteins Bind a Conserved RNA Sequence to Promote MicroRNA Maturation by Drosha [J].

Davis, Brandi N. ;

Hilyard, Aaron C. ;

Nguyen, Peter H. ;

Lagna, Giorgio ;

Hata, Akiko .

MOLECULAR CELL, 2010, 39 (03) :373-384

[7] Regulation of MicroRNA Biogenesis: A miRiad of mechanisms [J].

Davis, Brandi N. ;

Hata, Akiko .

CELL COMMUNICATION AND SIGNALING, 2009, 7

[8] Mechanisms of control of microRNA biogenesis [J].

Davis-Dusenbery, Brandi N. ;

Hata, Akiko .

JOURNAL OF BIOCHEMISTRY, 2010, 148 (04) :381-392

[9]

Endoh H, 1999, MOL CELL BIOL, V19, P5363

[10] Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? [J].

Filipowicz, Witold ;

Bhattacharyya, Suvendra N. ;

Sonenberg, Nahum .

NATURE REVIEWS GENETICS, 2008, 9 (02) :102-114

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