Insulin Resistance: From Mechanisms to Therapeutic Strategies

被引：450

作者：

Lee, Shin-Hae ^{[1
]}

Park, Shi-Young ^{[1
]}

Choi, Cheol Soo ^{[1
,2
,3
]}

机构：

[1] Gachon Univ, Korea Mouse Metab Phenotyping Ctr KMMPC, Lee Gil Ya Canc & Diabet Inst, Incheon, South Korea

[2] Gachon Univ, Dept Internal Med, Gil Med Ctr, Incheon, South Korea

[3] Gachon Univ, Div Mol Med, Coll Med, 21 Namdong Daero 774beon Gil, Incheon 21565, South Korea

来源：

DIABETES & METABOLISM JOURNAL | 2022年 / 46卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

Diabetes mellitus; type; 2; Insulin resistance; Metabolic syndrome; Therapeutics; PROTEIN-KINASE-C; INDUCED HEPATIC STEATOSIS; ELEMENT-BINDING PROTEIN; NECROSIS-FACTOR-ALPHA; GLUCOSE-INDUCED DESENSITIZATION; HEXOSAMINE SYNTHESIS PATHWAY; MUSCLE GLYCOGEN-SYNTHESIS; ACTIVATED RECEPTOR-GAMMA; FATTY-ACID OXIDATION; DIET-INDUCED OBESITY;

D O I：

10.4093/dmj.2021.0280

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Insulin resistance is the pivotal pathogenic component of many metabolic diseases, including type 2 diabetes mellitus, and is defined as a state of reduced responsiveness of insulin-targeting tissues to physiological levels of insulin. Although the underlying mechanism of insulin resistance is not fully understood, several credible theories have been proposed. In this review, we summarize the functions of insulin in glucose metabolism in typical metabolic tissues and describe the mechanisms proposed to underlie insulin resistance, that is, ectopic lipid accumulation in liver and skeletal muscle, endoplasmic reticulum stress, and inflammation. In addition, we suggest potential therapeutic strategies for addressing insulin resistance.

引用

页码：15 / 37

页数：23

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