Role of the brain melanocortins in blood pressure regulation

被引：22

作者：

do Carmo, Jussara M. ^{[1
]}

da Silva, Alexandre A. ^{[1
,2
,3
]}

Wang, Zhen ^{[1
]}

Fang, Taolin ^{[1
]}

Aberdein, Nicola ^{[1
]}

Perez de Lara, Cecilia E. ^{[1
]}

Hall, John E. ^{[1
]}

机构：

[1] Univ Mississippi, Med Ctr, Cardiovasc Renal Res Ctr, Dept Physiol & Biophys,Mississippi Ctr Obes Res, Jackson, MS 39216 USA

[2] Barao de Maua Univ Ctr, Sao Paulo, Brazil

[3] Univ Estadual Minas Gerais, Passos, MG, Brazil

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2017年 / 1863卷 / 10期

关键词：

Hypertension; Sympathetic activity; Obesity; Pro-opiomelanocortin; Melanocortin-4; receptor; MELANOCYTE-STIMULATING HORMONE; OBESITY-INDUCED HYPERTENSION; CENTRAL-NERVOUS-SYSTEM; SALT-SENSITIVE HYPERTENSION; NUCLEUS-TRACTUS-SOLITARII; CARDIOVASCULAR FUNCTION; ALPHA-MSH; ARTERIAL-PRESSURE; HEMORRHAGIC-SHOCK; RENAL-FUNCTION;

D O I：

10.1016/j.bbadis.2017.03.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Melanocortins play an important role in regulating blood pressure (BP) and sympathetic nervous system (SNS) activity as well as energy balance, glucose and other metabolic functions in humans and experimental animals. In experimental models of hypertension with high SNS activity, blockade of the melanocortin-4 receptor (MC4R) reduces BP despite causing marked hyperphagia and obesity. Activation of the central nervous system (CNS) proopiomelanocortin (POMC) MC4R pathway appears to be an important link between obesity, SNS activation and hypertension. Despite having severe obesity, subjects with MC4R deficiency exhibit reductions in BP, heart rate, and urinary catecholamine excretion, as well as attenuated SNS responses to cold stimuli compared to obese subjects with normal MC4R function. In this review we discuss the importance of the brain POMC-MC4R system in regulating SNS activity and BP in obesity and other forms of hypertension. We also highlight potential mechanisms and brain circuitry by which the melanocortin system regulates cardiovascular function.

引用

页码：2508 / 2514

页数：7

共 79 条

[1] Cardiac remodeling in obesity [J].