Does neoadjuvant therapy for pancreatic head adenocarcinoma increase postoperative morbidity? A systematic review of the literature with meta-analysis

被引：13

作者：

Araujo, Raphael L. C. ^{[1
,2
,3
]}

Silva, Raphael O. ^{[4
]}

de Padua Souza, Cristiano ^{[2
]}

Milani, Jean M. ^{[2
]}

Huguet, Florence ^{[5
]}

Rezende, Ana C. ^{[3
]}

Gaujoux, Sebastien ^{[6
]}

机构：

[1] Escola Paulista Med UNIFESP, Dept Digest Surg, Rua Botucatu,740,Vila Clementino, BR-04023062 Sao Paulo, SP, Brazil

[2] Barretos Canc Hosp, Postgrad Program, Barretos, SP, Brazil

[3] Einstein Sao Paulo Sao, Dept Oncol, Sao Paulo, SP, Brazil

[4] Hosp Santa Casa, Dept Surg Oncol, Campo Mourao, Parana, Brazil

[5] Sorbonne Univ, Hop Tenon, AP HP, Dept Radiat Oncol, Paris, France

[6] Hop Cochin, AP HP, Dept Digest Pancreat & Endocrine Surg, Paris, France

来源：

JOURNAL OF SURGICAL ONCOLOGY | 2020年 / 121卷 / 05期

关键词：

chemoradiotherapy; chemotherapy; morbidity; neoadjuvant treatment; pancreatic cancer; radiotherapy; GEMCITABINE-BASED CHEMORADIATION; LOCALLY ADVANCED ADENOCARCINOMA; PREOPERATIVE CHEMORADIATION; RESECTABLE ADENOCARCINOMA; HOSPITAL VOLUME; LOCALIZED ADENOCARCINOMA; DUCTAL ADENOCARCINOMA; PUBLICATION BIAS; II TRIAL; CANCER;

D O I：

10.1002/jso.25851

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Neoadjuvant treatment (NT) for pancreatic head cancer may allow some patients to undergo curative resection, but its impact on postoperative complications remains unclear. A systematic review and meta-analysis were performed to compare overall postoperative morbidity, pancreatic fistula, and mortality between patients who underwent upfront surgery and those who underwent neoadjuvant therapy first. Forty-five studies with 3359 patients were included. No significant differences in morbidity and mortality rates associated with NT for pancreatic head cancer were detected in this study.

引用

页码：881 / 892

页数：12

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