EPR examination of Zn2+ and Cu2+ effect on free radicals in DOPA-melanin-netilmicin complexes

被引：33

作者：

Buszman, E

Pilawa, B

Zdybel, M

Wrzesniok, D

Grzegorczyk, A

Wilczok, T

机构：

[1] Med Univ Silesia, Sch Pharm, Dept Pharmaceut Chem, PL-41200 Sosnowiec, Poland

[2] Med Univ Silesia, Sch Pharm, Dept Phys Med, PL-41200 Sosnowiec, Poland

[3] Med Univ Silesia, Sch Pharm, Dept Mol Biol & Genet, PL-41200 Sosnowiec, Poland

来源：

CHEMICAL PHYSICS LETTERS | 2005年 / 403卷 / 1-3期

关键词：

D O I：

10.1016/j.cplett.2004.12.069

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

DOPA-melanin and its complexes with netilmicin and metal ions (Zn2+,Cu2+) were examined by EPR spectroscopy. Broad EPR lines of o-semiquinone free radicals and paramagnetic Cu2+ were measured. Netilmicin slightly increased free radicals concentration in DOPA-melanin. Diamagnetic Zn2+ and paramagnetic Cu2+ ions increased and decreased, respectively, free radical concentrations in melanin-netilmicin complexes. Higher free radical concentrations were determined for (melanin-Zn2+)-netilmicin complexes than for (melanin-netilmicin)-Zn2+. Free radical concentrations were lower in (melanin-Cu2+)-netilmicin complexes than in (melanin-netilmicin)-Cu2+. Slow and fast spin-lattice relaxation processes were found for free radicals and Cu2+ systems in the samples. Netilmicin and Cu2+ increased spin-lattice relaxation time in melanin. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：22 / 28

页数：7

共 35 条

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