Iron-catalyzed synthesis of cinnarizine

被引：13
|
作者：
Shakhmaev, R. N. [1 ]
Sunagatullina, A. Sh [1 ]
Zorin, V. V. [1 ]
机构：
[1] Ufa State Petr Technol Univ, Ufa 450062, Bashkortostan, Russia
来源：
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 51卷 / 01期
关键词：
STEREOSELECTIVE-SYNTHESIS; GRIGNARD-REAGENTS; ALLYLAMINES; VINYLATION;
D O I：
10.1134/S1070428015010169
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Cinnarizine was synthesized in a high yield by iron-catalyzed cross-coupling of phenylmagnesium chloride with 1-[(2E)-3-chloroprop-2-en-1-yl]-4-(diphenylmethyl)piperazine prepared by allylation of 1-(diphenylmethyl) piperazine with (E)-1,3-dichloropropene.
引用
收藏
页码：95 / 97
页数：3
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