Altered striatal dopamine D2 receptor density and dopamine transport in a patient with hepatic encephalopathy

被引：0

作者：

Weissenborn, K ^{[1
]}

Berding, G

Köstler, H

机构：

[1] Med Hsch Hannover, Dept Neurol, D-30623 Hannover, Germany

[2] Med Hsch Hannover, Dept Nucl Med, D-30623 Hannover, Germany

[3] Med Hsch Hannover, Dept Neuroradiol, D-30623 Hannover, Germany

来源：

METABOLIC BRAIN DISEASE | 2000年 / 15卷 / 03期

关键词：

D-2 dopamine receptor; dopamine transporter; hepatic encephalopathy;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A patient suffering from liver cirrhosis presented with a bradykinetic-rigid syndrome suspected as Parkinson's disease. A detailed work-up of the case revealed hepatic encephalopathy as the cause of the neurological symptomatology. An alteration of striatal dopamine D-2 receptor binding and dopamine re-uptake sites was demonstrated by I-123-iodobenzamide (IBZM) and I-123-beta -CIT single photon emission computed tomography (SPECT), respectively. It is suggested that the alteration of the dopamine re-uptake in cirrhotics may be the cause of an increased catabolism of dopamine in HE.

引用

页码：173 / 178

页数：6

共 13 条

[1] MONOAMINES AND METABOLITES IN AUTOPSIED BRAIN-TISSUE FROM CIRRHOTIC-PATIENTS WITH HEPATIC-ENCEPHALOPATHY
BERGERON, M
READER, TA
LAYRARGUES, GP
BUTTERWORTH, RF
[J]. NEUROCHEMICAL RESEARCH, 1989, 14 (09) : 853 - 859
[2] PORTAL-SYSTEMIC ENCEPHALOPATHY - A DISORDER OF NEURON-ASTROCYTIC METABOLIC TRAFFICKING
BUTTERWORTH, RF
[J]. DEVELOPMENTAL NEUROSCIENCE, 1993, 15 (3-5) : 313 - 319
[3] CONN HO, 1977, GASTROENTEROLOGY, V72, P573
[4] Hierholzer J, 1998, J NUCL MED, V39, P954
[5] Does ammonia contribute to increased GABA-ergic neurotransmission in liver failure?
Jones, EA
Basile, AS
[J]. METABOLIC BRAIN DISEASE, 1998, 13 (04) : 351 - 360
[6] Recent biochemical studies of the dopamine transporter - A CNS drug target
Kuhar, MJ
[J]. LIFE SCIENCES, 1998, 62 (17-18) : 1573 - 1575
[7] An image of the brain in patients with liver disease
Lockwood, AH
Weissenborn, K
Butterworth, RF
[J]. CURRENT OPINION IN NEUROLOGY, 1997, 10 (06) : 525 - 533
[8] SELECTIVE LOSS OF PALLIDAL DOPAMINE-D(2) RECEPTOR DENSITY IN HEPATIC-ENCEPHALOPATHY
MOUSSEAU, DD
PERNEY, P
LAYRARGUES, GP
BUTTERWORTH, RF
[J]. NEUROSCIENCE LETTERS, 1993, 162 (1-2) : 192 - 196
[9] PIROZZOLO FJ, 1988, PARKINSONS DISEASE M, P425
[10] INCREASED ACTIVITIES OF MAO(A) AND MAO(B) IN AUTOPSIED BRAIN-TISSUE FROM CIRRHOTIC-PATIENTS WITH HEPATIC-ENCEPHALOPATHY
RAO, VLR
GIGUERE, JF
LAYRARGUES, GP
BUTTERWORTH, RF
[J]. BRAIN RESEARCH, 1993, 621 (02) : 349 - 352

← 1 2 →