Immunomodulatory effects of stem cells: Therapeutic option for neurodegenerative disorders

被引：21

作者：

Caprnda, Martin ^{[1
,2
]}

Kubatka, Peter ^{[3
,4
]}

Gazdikova, Katarina ^{[5
,6
]}

Gasparova, Iveta ^{[2
,7
]}

Valentova, Vanda ^{[3
]}

Stollarova, Nadezda ^{[8
]}

La Rocca, Giampiero ^{[9
,10
]}

Kobyliak, Nazarii ^{[11
]}

Dragasek, Jozef ^{[12
,13
]}

Mozos, Ioana ^{[14
]}

Prosecky, Robert ^{[15
]}

Siniscalco, Dario ^{[16
]}

Busselberg, Dietrich ^{[17
]}

Rodrigo, Luis ^{[18
]}

Kruzliak, Peter ^{[19
,20
]}

机构：

[1] Comenius Univ, Fac Med, Dept Internal Med 1, Bratislava, Slovakia

[2] Univ Hosp, Bratislava, Slovakia

[3] Comenius Univ, Jessenius Fac Med, Dept Med Biol, Martin, Slovakia

[4] Comenius Univ, Jessenius Fac Med, Biomed Ctr Martin, Div Oncol, Bratislava, Slovakia

[5] Slovak Med Univ, Fac Nursing & Profess Hlth Studies, Dept Nutr, Bratislava, Slovakia

[6] Slovak Med Univ, Fac Med, Dept Gen Med, Bratislava, Slovakia

[7] Comenius Univ, Fac Med, Inst Biol Genet & Med Genet, Bratislava, Slovakia

[8] Catholic Univ Ruzomberok, Fac Pedag, Dept Biol & Ecol, Ruzomberok, Slovakia

[9] Univ Palermo, Dept Expt Biomed & Clin Neurosci, Human Anat Sect, Palermo, Italy

[10] Euro Mediterranean Inst Sci & Technol IEMEST, Palermo, Italy

[11] Bogomolets Natl Med Univ, Endocrinol Dept, Kiev, Ukraine

[12] Pavol Jozef Safarik Univ, Fac Med, Dept Psychiat 1, Kosice, Slovakia

[13] Univ Hosp, Kosice, Slovakia

[14] Victor Babes Univ Med & Pharm, Discipline Pathophysiol, Dept Funct Sci, Timisoara, Romania

[15] Merciful Bros Hosp, Dept Internal Med, Brno, Czech Republic

[16] Univ Campania Luigi Vanvitelli, Dept Expt Med, Naples, Italy

[17] Qatar Fdn Educ City, Weill Cornell Med Coll, Doha, Qatar

[18] Univ Oviedo, Cent Univ Hosp Asturias HUCA, Oviedo, Spain

[19] Univ Vet & Pharmaceut Sci, Fac Pharm, Dept Chem Drugs, Brno, Czech Republic

[20] St Annes Univ Hosp, Fac Med, Dept Surg 2, Brno, Czech Republic

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2017年 / 91卷

关键词：

Stem cell therapy; Neurodegenerative disorders; Regenerative medicine; MESENCHYMAL STROMAL CELLS; AMYOTROPHIC-LATERAL-SCLEROSIS; FUNCTIONAL DOPAMINE NEURONS; NEURAL PROGENITOR CELLS; AMYLOID-BETA DEPOSITION; ANIMAL-MODEL; RAT MODEL; REGENERATIVE MEDICINE; PARKINSONS-DISEASE; BONE-MARROW;

D O I：

10.1016/j.biopha.2017.04.034

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Stem cells have the capability of self-renewal and can differentiate into different cell types that might be used in regenerative medicine. Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS) currently lack effective treatments. Although stem cell therapy is still on the way from bench to bedside, we consider that it might provide new hope for patients suffering with neurodegenerative diseases. In this article, we will give an overview of recent studies on the potential therapeutic use of mesenchymal stem cells (MSCs), neural stem cells (NSCs), embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and perinatal stem cells to neurodegenerative disorders and we will describe their immunomodulatory mechanisms of action in specific therapeutic modalities. (C) 2017 Elsevier Masson SAS. All rights reserved.

引用

页码：60 / 69

页数：10

共 124 条

[1] The New Federalism: State Policies Regarding Embryonic Stem Cell Research [J].