Immunomodulatory effect of bergenin and norbergenin against adjuvant-induced arthritis - A flow cytometric study

被引:127
|
作者
Nazir, Nighat [1 ]
Koul, Surrinder
Qurishi, Mushtaq A.
Taneja, Sachin C.
Ahmad, Sheikh F.
Ani, Sarang B.
Qazi, Ghulam N.
机构
[1] Univ Kashmir, Dept Chem, Srinagar 190006, Jammu & Kashmir, India
[2] Reg Res Lab, Div Biotechnol, Jammu 180001, India
[3] Reg Res Lab, Div Pharmacol, Jammu 180001, India
关键词
Saxifragaceae; Bergenia stracheyi; Bergenin; norbergenin; flowcytometry; inimunomodulatory activity;
D O I
10.1016/j.jep.2007.02.023
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Bergenin (1), a C-glycoside of 4-O-methyl gallic acid, isolated from rhizomes of Bergenia stracheyi (Saxifragaceae) and its O-demethylated derivative norbergenin (2), prepared from 1, are reported to show anti-arthritic activity through possible modulation of Th1/Th2 cytokine balance. Flow cytometric study showed that the oral administration of 1 and 2 at doses of 5, 10, 20, 40 and 80 mg/kg per oral dose inhibit the production of proinflammatory Th1 cytokines (IL-2, IFN-gamma and TNF-alpha) while as potentiate anti-inflammatory Th2 cytokines (IL-4 and IL-5) in the peripheral blood of adjuvant-induced arthritic balb/c mice. This shows the potential Th1/Th2 cytokine balancing activity of 1 and 2 which is strongly correlated with their anti-arthritic activity. At similar dose levels, the effect of 2 was found to be more than that of 1. The oral LD0 for 1 and 2 was more than 2000 mg/kg body weight of the mice. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:401 / 405
页数:5
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