Novel glutamatergic agents for major depressive disorder and bipolar disorder

被引：70

作者：

Machado-Vieira, Rodrigo ^{[2
]}

Ibrahim, Lobna ^{[1
]}

Henter, Loline D. ^{[3
]}

Zarate, Carlos A., Jr. ^{[1
]}

机构：

[1] NIMH, Expt Therapeut & Pathophysiol Branch, Intramural Res Program, NIH, Bethesda, MD 20892 USA

[2] Univ Sao Paulo, Sch Med, L1M 27, Inst & Dept Psychiat,USP, Sao Paulo, Brazil

[3] NIMH, Mol Imaging Branch, Intramural Res Program, NIH, Bethesda, MD 20892 USA

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 2012年 / 100卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Bipolar disorder; Depression; Glutamate; Mood disorders; Novel treatments; Pathophysiology; MAGNETIC-RESONANCE-SPECTROSCOPY; D-ASPARTATE ANTAGONIST; OPEN-LABEL TRIAL; STAR-ASTERISK-D; SEROTONIN REUPTAKE INHIBITORS; OBSESSIVE-COMPULSIVE DISORDER; RAPID ANTIDEPRESSANT RESPONSE; ANTERIOR CINGULATE ACTIVITY; MGLU5 RECEPTOR ANTAGONIST; GAMMA-AMINOBUTYRIC-ACID;

D O I：

10.1016/j.pbb.2011.09.010

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Mood disorders such as major depressive disorder (MDD) and bipolar disorder (BPD) are common, chronic, recurrent mental illnesses that affect the lives and functioning of millions of individuals worldwide. Growing evidence suggests that the glutamatergic system is central to the neurobiology and treatment of these disorders. Here, we review data supporting the involvement of the glutamatergic system in the pathophysiology of mood disorders as well as the efficacy of glutamatergic agents as novel therapeutics. Published by Elsevier Inc.

引用

页码：678 / 687

页数：10

共 180 条

[41] Riluzole enhances glutamate uptake in rat astrocyte cultures [J].

Frizzo, MED ;

Dall'Onder, LP ;

Dalcin, KB ;

Souza, DO .

CELLULAR AND MOLECULAR NEUROBIOLOGY, 2004, 24 (01) :123-128

[42] Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1 [J].

Fumagalli, Elena ;

Funicello, Marcella ;

Rauen, Thomas ;

Gobbi, Marco ;

Mennini, Tiziana .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2008, 578 (2-3) :171-176

[43] Acute administration of ketamine induces antidepressant-like effects in the forced swimming test and increases BDNF levels in the rat hippocampus [J].

Garcia, Leda S. B. ;

Comim, Clarissa M. ;

Valvassori, Samira S. ;

Reus, Gislaine Z. ;

Barbosa, Luciana M. ;

Andreazza, Ana Cristina ;

Stertz, Laura ;

Fries, Gabriel R. ;

Gavioli, Elaine Cristina ;

Kapczinski, Flavio ;

Quevedo, Joao .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2008, 32 (01) :140-144

[44]

Gasparini F, 1999, J PHARMACOL EXP THER, V289, P1678

[45] Rapid relief of severe major depressive disorder by use of preoperative ketamine and electroconvulsive therapy [J].

Goforth, Harold W. ;

Holsinger, Tracey .

JOURNAL OF ECT, 2007, 23 (01) :23-25

[46] Pro-survival signalling from the NMDA receptor [J].

Hardingham, G. E. .

BIOCHEMICAL SOCIETY TRANSACTIONS, 2006, 34 :936-938

[47] Increased levels of glutamate in brains from patients with mood disorders [J].

Hashimoto, Kenji ;

Sawa, Akira ;

Iyo, Masaomi .

BIOLOGICAL PSYCHIATRY, 2007, 62 (11) :1310-1316

[48] Lithium protection against glutamate excitotoxicity in rat cerebral cortical neurons: involvement of NMDA receptor inhibition possibly by decreasing NR2B tyrosine phosphorylation [J].

Hashimoto, R ;

Hough, C ;

Nakazawa, T ;

Yamamoto, T ;

Chuang, DM .

JOURNAL OF NEUROCHEMISTRY, 2002, 80 (04) :589-597

[49] Reduced prefrontal glutamate/glutamine and γ-aminobutyric acid levels in major depression determined using proton magnetic resonance spectroscopy [J].

Hasler, Gregor ;

van der Veen, Jan Willem ;

Tumonis, Toni ;

Meyers, Noah ;

Shen, Jun ;

Drevets, Wayne C. .

ARCHIVES OF GENERAL PSYCHIATRY, 2007, 64 (02) :193-200

[50] Up-regulation of hippocampal glutamate transport during chronic treatment with sodium valproate [J].

Hassel, B ;

Iversen, EG ;

Gjerstad, L ;

Tauboll, E .

JOURNAL OF NEUROCHEMISTRY, 2001, 77 (05) :1285-1292

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