Novel glutamatergic agents for major depressive disorder and bipolar disorder

被引：69
作者：
Machado-Vieira, Rodrigo [2 ]
Ibrahim, Lobna [1 ]
Henter, Loline D. [3 ]
Zarate, Carlos A., Jr. [1 ]
机构：
[1] NIMH, Expt Therapeut & Pathophysiol Branch, Intramural Res Program, NIH, Bethesda, MD 20892 USA
[2] Univ Sao Paulo, Sch Med, L1M 27, Inst & Dept Psychiat,USP, Sao Paulo, Brazil
[3] NIMH, Mol Imaging Branch, Intramural Res Program, NIH, Bethesda, MD 20892 USA
来源：
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 2012年 / 100卷 / 04期
基金：
美国国家卫生研究院;
关键词：
Bipolar disorder; Depression; Glutamate; Mood disorders; Novel treatments; Pathophysiology; MAGNETIC-RESONANCE-SPECTROSCOPY; D-ASPARTATE ANTAGONIST; OPEN-LABEL TRIAL; STAR-ASTERISK-D; SEROTONIN REUPTAKE INHIBITORS; OBSESSIVE-COMPULSIVE DISORDER; RAPID ANTIDEPRESSANT RESPONSE; ANTERIOR CINGULATE ACTIVITY; MGLU5 RECEPTOR ANTAGONIST; GAMMA-AMINOBUTYRIC-ACID;
D O I：
10.1016/j.pbb.2011.09.010
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Mood disorders such as major depressive disorder (MDD) and bipolar disorder (BPD) are common, chronic, recurrent mental illnesses that affect the lives and functioning of millions of individuals worldwide. Growing evidence suggests that the glutamatergic system is central to the neurobiology and treatment of these disorders. Here, we review data supporting the involvement of the glutamatergic system in the pathophysiology of mood disorders as well as the efficacy of glutamatergic agents as novel therapeutics. Published by Elsevier Inc.
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收藏
页码：678 / 687
页数：10
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