The dynamic control of signal transduction networks in cancer cells

被引：261

作者：

Kolch, Walter ^{[1
,2
,3
]}

Halasz, Melinda ^{[1
]}

Granovskaya, Marina ^{[4
]}

Kholodenko, Boris N. ^{[1
,2
,3
]}

机构：

[1] Univ Coll Dublin, Syst Biol Ireland, Dublin, Ireland

[2] Univ Coll Dublin, Conway Inst Biomol & Biomed Res, Dublin, Ireland

[3] Univ Coll Dublin, Sch Med & Med Sci, Dublin 4, Ireland

[4] Roche Moscow Ltd, Business Ctr, Moscow 107031, Russia

来源：

NATURE REVIEWS CANCER | 2015年 / 15卷 / 09期

基金：

爱尔兰科学基金会;

关键词：

CYCLIN-DEPENDENT KINASES; TUMOR-SUPPRESSOR STATUS; NEGATIVE FEEDBACK; TRANSCRIPTIONAL REGULATION; BRAF(V600E) INHIBITION; MESENCHYMAL TRANSITION; MOLECULAR-MECHANISMS; PATHWAY ACTIVATION; RESTRICTION POINT; REGULATED KINASE;

D O I：

10.1038/nrc3983

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer is often considered a genetic disease. However, much of the enormous plasticity of cancer cells to evolve different phenotypes, to adapt to challenging microenvironments and to withstand therapeutic assaults is encoded by the structure and spatiotemporal dynamics of signal transduction networks. In this Review, we discuss recent concepts concerning how the rich signalling dynamics afforded by these networks are regulated and how they impinge on cancer cell proliferation, survival, invasiveness and drug resistance. Understanding this dynamic circuitry by mathematical modelling could pave the way to new therapeutic approaches and personalized treatments.

引用

页码：515 / 527

页数：13

共 145 条

[1] Frequency-Modulated Pulses of ERK Activity Transmit Quantitative Proliferation Signals [J].

Albeck, John G. ;

Mills, Gordon B. ;

Brugge, Joan S. .

MOLECULAR CELL, 2013, 49 (02) :249-261

[2] Inference of Tumor Evolution during Chemotherapy by Computational Modeling and In Situ Analysis of Genetic and Phenotypic Cellular Diversity [J].

Almendro, Vanessa ;

Cheng, Yu-Kang ;

Randles, Amanda ;

Itzkovitz, Shalev ;

Marusyk, Andriy ;

Ametller, Elisabet ;

Gonzalez-Farre, Xavier ;

Munoz, Montse ;

Russnes, Hege G. ;

Helland, Aslaug ;

Rye, Inga H. ;

Borresen-Dale, Anne-Lise ;

Maruyama, Reo ;

van Oudenaarden, Alexander ;

Dowsett, Mitchell ;

Jones, Robin L. ;

Reis-Filho, Jorge ;

Gascon, Pere ;

Goenen, Mithat ;

Michor, Franziska ;

Polyak, Kornelia .

CELL REPORTS, 2014, 6 (03) :514-527

[3] A module of negative feedback regulators defines growth factor signaling [J].

Amit, Ido ;

Citri, Ami ;

Shay, Tal ;

Lu, Yiling ;

Katz, Menachem ;

Zhang, Fan ;

Tarcic, Gabi ;

Siwak, Doris ;

Lahad, John ;

Jacob-Hirsch, Jasmine ;

Amariglio, Ninette ;

Vaisman, Nora ;

Segal, Eran ;

Rechavi, Gideon ;

Alon, Uri ;

Mills, Gordon B. ;

Domany, Eytan ;

Yarden, Yosef .

NATURE GENETICS, 2007, 39 (04) :503-512

[4] The ins and Outs of the Epithelial to Mesenchymal Transition in Health and Disease [J].

Angela Nieto, M. .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 27, 2011, 27 :347-376

[5] Fluorescence resonance energy transfer imaging of cell signaling from in vitro to in vivo: Basis of biosensor construction, live imaging, and image processing [J].

Aoki, Kazuhiro ;

Kamioka, Yuji ;

Matsuda, Michiyuki .

DEVELOPMENT GROWTH & DIFFERENTIATION, 2013, 55 (04) :515-522

[6] The history and future of targeting cyclin-dependent kinases in cancer therapy [J].

Asghar, Uzma ;

Witkiewicz, Agnieszka K. ;

Turner, Nicholas C. ;

Knudsen, Erik S. .

NATURE REVIEWS DRUG DISCOVERY, 2015, 14 (02) :130-146

[7] Protein kinases of the Hippo pathway: Regulation and substrates [J].

Avruch, Joseph ;

Zhou, Dawang ;

Fitamant, Julien ;

Bardeesy, Nabeel ;

Mou, Fan ;

Barrufet, Laura Regue .

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2012, 23 (07) :770-784

[8] Mammalian Hippo pathway: from development to cancer and beyond [J].

Bao, Yijun ;

Hata, Yutaka ;

Ikeda, Mitsunobu ;

Withanage, Kanchanamala .

JOURNAL OF BIOCHEMISTRY, 2011, 149 (04) :361-379

[9] Dissecting cancer evolution at the macro-heterogeneity and micro-heterogeneity scale [J].

Barber, Louise J. ;

Davies, Matthew N. ;

Gerlinger, Marco .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2015, 30 :1-6

[10] Stimulus-dependent dynamics of p53 in single cells [J].

Batchelor, Eric ;

Loewer, Alexander ;

Mock, Caroline ;

Lahav, Galit .

MOLECULAR SYSTEMS BIOLOGY, 2011, 7

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