The dynamic control of signal transduction networks in cancer cells

被引：254
作者：
Kolch, Walter [1 ,2 ,3 ]
Halasz, Melinda [1 ]
Granovskaya, Marina [4 ]
Kholodenko, Boris N. [1 ,2 ,3 ]
机构：
[1] Univ Coll Dublin, Syst Biol Ireland, Dublin, Ireland
[2] Univ Coll Dublin, Conway Inst Biomol & Biomed Res, Dublin, Ireland
[3] Univ Coll Dublin, Sch Med & Med Sci, Dublin 4, Ireland
[4] Roche Moscow Ltd, Business Ctr, Moscow 107031, Russia
来源：
NATURE REVIEWS CANCER | 2015年 / 15卷 / 09期
基金：
爱尔兰科学基金会;
关键词：
CYCLIN-DEPENDENT KINASES; TUMOR-SUPPRESSOR STATUS; NEGATIVE FEEDBACK; TRANSCRIPTIONAL REGULATION; BRAF(V600E) INHIBITION; MESENCHYMAL TRANSITION; MOLECULAR-MECHANISMS; PATHWAY ACTIVATION; RESTRICTION POINT; REGULATED KINASE;
D O I：
10.1038/nrc3983
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cancer is often considered a genetic disease. However, much of the enormous plasticity of cancer cells to evolve different phenotypes, to adapt to challenging microenvironments and to withstand therapeutic assaults is encoded by the structure and spatiotemporal dynamics of signal transduction networks. In this Review, we discuss recent concepts concerning how the rich signalling dynamics afforded by these networks are regulated and how they impinge on cancer cell proliferation, survival, invasiveness and drug resistance. Understanding this dynamic circuitry by mathematical modelling could pave the way to new therapeutic approaches and personalized treatments.
引用
收藏
页码：515 / 527
页数：13
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