Hematopoietic development: a balancing act

被引:160
作者
Cantor, AB [1 ]
Orkin, SH [1 ]
机构
[1] Childrens Hosp, Div Hematol Oncol, Boston, MA 02115 USA
关键词
D O I
10.1016/S0959-437X(00)00226-4
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Over the past year, significant new insights have been gained in our understanding of the lineage determination of red blood cells. In particular, evidence has emerged demonstrating that cross-antagonism of lineage-specific transcription factors plays an important role in determining cell phenotype by actively repressing alternate lineage gene programs.
引用
收藏
页码:513 / 519
页数:7
相关论文
共 43 条
[1]   PAX-5 ENCODES THE TRANSCRIPTION FACTOR BSAP AND IS EXPRESSED IN LYMPHOCYTES-B, THE DEVELOPING CNS, AND ADULT TESTIS [J].
ADAMS, B ;
DORFLER, P ;
AGUZZI, A ;
KOZMIK, Z ;
URBANEK, P ;
MAURERFOGY, I ;
BUSSLINGER, M .
GENES & DEVELOPMENT, 1992, 6 (09) :1589-1607
[2]  
BARLETT PF, 1982, P NATL ACAD SCI USA, V79, P2722
[3]   Turning brain into blood: A hematopoietic fate adopted by adult neural stem cells in vivo [J].
Bjornson, CRR ;
Rietze, RL ;
Reynolds, BA ;
Magli, MC ;
Vescovi, AL .
SCIENCE, 1999, 283 (5401) :534-537
[4]   From marrow to brain: Expression of neuronal phenotypes in adult mice [J].
Brazelton, TR ;
Rossi, FMV ;
Keshet, GI ;
Blau, HM .
SCIENCE, 2000, 290 (5497) :1775-1779
[5]   Generalized potential of adult neural stem cells [J].
Clarke, DL ;
Johansson, CB ;
Wilbertz, J ;
Veress, B ;
Nilsson, E ;
Karlström, H ;
Lendahl, U ;
Frisén, J .
SCIENCE, 2000, 288 (5471) :1660-1663
[6]   Use of altered specificity mutants to probe a specific protein-protein interaction in differentiation:: The GATA-1:FOG complex [J].
Crispino, JD ;
Lodish, MB ;
MacKay, JP ;
Orkin, SH .
MOLECULAR CELL, 1999, 3 (02) :219-228
[7]  
EMERSON SG, 1991, HEMATOLOGY BASIC PRI, P72
[8]   Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia [J].
Ferber, S ;
Halkin, A ;
Cohen, H ;
Ber, I ;
Einav, Y ;
Goldberg, I ;
Barshack, I ;
Seijffers, R ;
Kopolovic, J ;
Kaiser, N ;
Karasik, A .
NATURE MEDICINE, 2000, 6 (05) :568-572
[9]   Transcriptional cofactors of the FOG family interact with GATA proteins by means of multiple zinc fingers [J].
Fox, AH ;
Liew, C ;
Holmes, M ;
Kowalski, K ;
Mackay, J ;
Crossley, M .
EMBO JOURNAL, 1999, 18 (10) :2812-2822
[10]   Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1 [J].
Fujiwara, Y ;
Browne, CP ;
Cunniff, K ;
Goff, SC ;
Orkin, SH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (22) :12355-12358