Relationship between plasma YKL-40 levels and endothelial dysfunction in chronic kidney disease

被引：9

作者：

Keskin, Gul Sema ^{[1
]}

Helvaci, Ozant ^{[2
]}

Yayla, Cagri ^{[3
]}

Pasaoglu, Ozge T. ^{[4
]}

Keskin, Caglar ^{[5
]}

Arinsoy, Turgay ^{[2
]}

Deric, Ulver B. ^{[2
]}

机构：

[1] Baskent Univ, Fac Med, Dept Oncol, Ankara, Turkey

[2] Gazi Univ, Fac Med, Dept Nephrol, Ankara, Turkey

[3] Yuksek Ihtisas Hosp, Dept Cardiol, Ankara, Turkey

[4] Gazi Univ, Fac Sci, Dept Biochem, Ankara, Turkey

[5] Ankara Univ, Fac Med, Dept Endocrinol, Ankara, Turkey

来源：

TURKISH JOURNAL OF MEDICAL SCIENCES | 2019年 / 49卷 / 01期

关键词：

YKL-40; CKD; hemodialysis; atherosclerosis; endothelial dysfunction; CHITINASE FAMILY; MATRIX PROTEIN; EARLY-STAGE; SERUM; MARKER; ATHEROSCLEROSIS; BIOMARKER; GRANULES; CHI3L1; MEMBER;

D O I：

10.3906/sag-1804-169

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background/aim: We aimed to evaluate the relationship between YKL-40 and endothelial dysfunction in chronic kidney disease. Materials and methods: Twenty-nine hemodialysis patients, 101 patients with nondialytic (stage 2, 3, 4, and 5 ND) chronic kidney disease (CKD), and 38 healthy individuals as a control group were included. YKL-40 levels were measured by ELISA. Endothelial dysfunction was indirectly measured by flow-mediated dilatation percentage (FMD) in the brachial artery. Results: YKL-40 levels were higher in CKD patients than controls and highest in HD patients (P = 0.001). FMD values were lower in nondialytic CKD patients and lowest in HD patients (P = 0.001). YKL-40 negatively correlated with eGFR and FMD values (r = -0.674 and r = -0.471, respectively). Conclusion: This study shows that YKL-40 increases with CKD stage and is negatively correlated with FMD measurements.

引用

收藏

页码：139 / 146

页数：8

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