Age-related Mitochondrial Dysfunction in Parkinson's Disease: New Insights Into the Disease Pathology

被引：9

作者：

Rani, Linchi ^{[1
]}

Sahu, Manas Ranjan ^{[1
]}

Mondal, Amal Chandra ^{[1
,2
]}

机构：

[1] Jawaharlal Nehru Univ, Sch Life Sci, Lab Cellular & Mol Neurobiol, New Delhi, India

[2] Jawaharlal Nehru Univ, Sch Life Sci, New Delhi 110067, India

来源：

NEUROSCIENCE | 2022年 / 499卷

关键词：

Aging; Parkinson?s disease; Mitochondrial quality control mechanism; Mitochondrial aberrations; PERMEABILITY TRANSITION PORE; FREE-RADICAL THEORY; ALPHA-SYNUCLEIN-A; OXIDATIVE STRESS; RESPIRATORY-CHAIN; DNA DELETIONS; LIFE-SPAN; NEURONAL VULNERABILITY; FUNCTIONAL IMPAIRMENT; INTRACELLULAR CALCIUM;

D O I：

10.1016/j.neuroscience.2022.07.007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

is a progressive loss of physiological function that increases risk of disease and death. Among the many factors that contribute to human aging, mitochondrial dysfunction has emerged as one of the most prominent features of the aging process. It has been linked to the development of various age-related pathologies, including Parkinson's disease (PD). Mitochondria has a complex quality control system that ensures mitochon-drial integrity and function. Perturbations in these mitochondrial mechanisms have long been linked to various age-related neurological disorders. Even though research has shed light on several aspects of the disease pathol-ogy, the underlying mechanism of age-related factors responsible for individuals developing this disease is still unknown. This review article aims to discuss the role of mitochondria in the transition from normal brain aging to pathological brain aging, which leads to the progression of PD. We have discussed the emerging evidence on how age-related disruption of mitochondrial quality control mechanisms contributes to the development of PD -related pathophysiology.(c) 2022 IBRO. Published by Elsevier Ltd. All rights reserved.

引用

页码：152 / 169

页数：18

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