Epidemiological assessment of continuing transmission of lymphatic filariasis in Samoa

被引：29
作者：
Joseph, H. [1 ]
Maiava, F.
Naseri, T.
Silva, U.
Lammie, P. [2 ]
Melrose, W.
机构：
[1] James Cook Univ, Sch Publ Hlth Trop Med & Rehabil Sci, Lymphat Filariasis Support Ctr, Townsville, Qld 4811, Australia
[2] Ctr Dis Control & Prevent, Atlanta, GA USA
来源：
ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY | 2011年 / 105卷 / 08期
关键词：
WUCHERERIA-BANCROFTI INFECTION; MASS TREATMENT; PACIFIC; ELIMINATION; ANTIGEN; MICROFILAREMIA; DETERMINANTS; INDIVIDUALS; ANTIBODIES; DIAGNOSIS;
D O I：
10.1179/2047773211Y.0000000008
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Ongoing transmission of lymphatic filariasis (LF) was assessed in five Samoan villages by measuring microfilaraemia (Mf), circulating filarial antigen (CFA) and antibody prevalence. Compared to the other villages, Fasitoo-Tai had a significantly higher Mf prevalence (3.2%), CFA prevalence (14.6%) and antibody prevalence in children (62.0%) (P<0.05). Puapua had a significantly lower CFA prevalence (2.5%), no detectable Mf-positive individuals and significantly low antibody prevalence in children (7.9%) (P<0.05). Siufaga, previously believed to be LF-free, recorded >1% CFA prevalence and a high antibody prevalence in children (46.6%). Overall, antibody prevalence in children appeared to reflect the transmission dynamics in the villages and, in Siufaga, identified an area of ongoing transmission. The Filariasis Cellabs Enzyme-Linked Immunosorbent Assay (CELISA), based on recombinant antigen Bm14, to detect antibodies, could potentially be a promising diagnostic tool for inclusion in future surveillance in the South Pacific.
引用
收藏
页码：567 / 578
页数：12
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