Antibacterial activity of the aqueous extract of Thonningia sanguinea against Extended-Spectrum-β-Lactamases (ESBL) producing Escherichia coli and Klebsiella pneumoniae strains

被引：0
|
作者：
N'guessan, J. D. [1 ]
Dinzedi, M. R. [1 ,2 ]
Guessennd, N. [2 ]
Coulibaly, A. [1 ]
Dosso, M. [2 ,3 ]
Djaman, A. J. [3 ]
Guede-Guina, F. [1 ]
机构：
[1] Lab Pharmcodynam Biochim, Abidjan 22, Cote Ivoire
[2] Inst Pasteur Cote Divoire, Dept Bacteriol & Virol, Abidjan 01, Cote Ivoire
[3] Inst Pasteur Cote Divoire, Biochim Lab, Abidjan, Cote Ivoire
来源：
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH | 2007年 / 6卷 / 03期
关键词：
antimicrobial activity; Thonningia sanguinea; ESBL producing strains; E; coli;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Purpose: The aim of this study was to evaluate the antimicrobial activity of Thonningia sanguinea against two sensitive and two multi-drug resistant ( ESBL) Enterobacteria strains namely Escherichia coli and Klebsiella pneumoniae. Method: The confirmation of the ESBL producing strains was done by the double-disc synergy tests and the broth dilution method was used for the determination of the antimicrobial parameters ( MIC and MBC) on these sensitive and ESBL producing strains. Results: The two sensitive strains had the same MIC and MBC values respectively 3.125 mg/ml and 12.50 mg/ml. The ESBL producing strains also had the same MIC of 6.25 mg/ml and MBC values of 25 mg/ml. The extract was bactericidal for all tested strains. Conclusion: The results suggest that the flowers of T. sanguinea can be used in association with antibiotics for alternative therapy of diseases caused by ESBL producing E. coli, K. pneumoniae.
引用
收藏
页码：779 / 783
页数：5
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