Microwave-assisted synthesis of N1-and C3-substituted pyrazolo[3,4-d]pyrimidine libraries

被引：28

作者：

Todorovic, Nick ^{[1
]}

Awuah, Emelia ^{[1
]}

Shakya, Tushar ^{[2
]}

Wright, Gerard D. ^{[2
]}

Capretta, Alfredo ^{[1
]}

机构：

[1] McMaster Univ, Dept Chem & Chem Biol, Hamilton, ON L8S 4M1, Canada

[2] McMaster Univ, Dept Biochem & Biomed Sci, MG DeGroote Inst Infect Dis Res, Hamilton, ON L8S 3Z5, Canada

来源：

TETRAHEDRON LETTERS | 2011年 / 52卷 / 44期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Pyrazolo[3,4-d]pyrimidines; Pd-catalyzed cross coupling; Mitsunobu reaction; Microwave-assisted synthesis; Library synthesis; PHOSPHA-ADAMANTANE FRAMEWORK; CROSS-COUPLING REACTIONS; ARYL HALIDES; SUZUKI; LIGANDS; INHIBITORS; CHEMISTRY; DESIGN; POTENT;

D O I：

10.1016/j.tetlet.2011.08.103

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The parallel synthesis of a library N1- and C3-substituted-pyrazolo[3,4-d]pyrimidines is described. The microwave-assisted approach involves the de novo generation of the heterocyclic scaffold, facile alkylation at N1 via either a Mitsunobu or a direct alkylation reaction and arylation at C3 via a Suzuki reaction. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：5761 / 5763

页数：3

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