Composition of salivary microbiota in elderly subjects

被引：51

作者：

Ogawa, Taiji ^{[1
]}

Hirose, Yujiro ^{[2
]}

Honda-Ogawa, Mariko ^{[2
]}

Sugimoto, Minami ^{[3
]}

Sasaki, Satoshi ^{[3
]}

Kibi, Masahito ^{[1
]}

Kawabata, Shigetada ^{[2
]}

Ikebe, Kazunori ^{[1
]}

Maeda, Yoshinobu ^{[1
]}

机构：

[1] Osaka Univ, Dept Prosthodont Gerodontol & Oral Rehabil, Grad Sch Dent, 1-8 Yamadaoka, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Dept Oral & Mol Microbiol, Grad Sch Dent, 1-8 Yamadaoka, Suita, Osaka 5650871, Japan

[3] Univ Tokyo, Sch Publ Hlth, Dept Social & Prevent Epidemiol, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan

来源：

SCIENTIFIC REPORTS | 2018年 / 8卷

基金：

日本学术振兴会;

关键词：

BACTERIAL-FLORA; DENDRITIC CELLS; FRAILTY; DEFINITION; DYSBIOSIS; HEALTH;

D O I：

10.1038/s41598-017-18677-0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Frailty is gaining attention worldwide with the aging of society. Despite the potential lethality and multiple signs and symptoms in affected individuals, preclinical detection of early manifestations leading to frailty syndrome have not been established. We speculated that the composition of the oral microbiota is associated with general frailty, as well as a relationship between gut microbiota and general health condition. In the present study, we investigated the salivary microbiota composition in samples from healthy and frail elderly individuals using 165 rRNA sequencing analysis for characterization. We found a significant difference in diversity between elderly individuals living in a nursing home (EN) and healthy control (HC) subjects, as well as in the microbiota composition at the phyla level. A supervised orthogonal partial least squared discriminant analysis (OPLS-DA) revealed a significant difference in clear classification trend between the EN and HC groups, with all observations falling within the Hotellings T-2 (0.95) ellipse, with model fitness parameters of R-2 (cum) = 0.937 and Q(2) (cum) = 0.888, respectively. In addition, the score plots by unsupervised principal component analysis (PCA) showed a clear classification trend in both groups. Our findings suggest that general frailty is associated with oral microbiota composition and formation.

引用

页数：9

共 33 条

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