Treatment with an acetylcholinesterase inhibitor in Alzheimer patients modulates the expression and production of the pro-inflammatory and anti-inflammatory cytokines

被引：112

作者：

Reale, M

Iarlori, C

Gambi, F

Feliciani, C

Salone, A

Toma, L

DeLuca, G

Salvatore, M

Conti, P

Gambi, D

机构：

[1] Univ UDA, Dept Oncol & Neurosci, Neurol Unit, I-66013 Chieti, Italy

[2] Univ UDA, Dept Oncol & Neurosci, Dermatol Unit, I-66013 Chieti, Italy

[3] Univ UDA, Dept Oncol & Neurosci, Psychiat Unit, I-66013 Chieti, Italy

[4] Univ UDA, Dept Oncol & Neurosci, Immunol Unit, I-66013 Chieti, Italy

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2004年 / 148卷 / 1-2期

关键词：

Alzheimer's disease; IL-1; beta; IL-6; TNF alpha; IL-4; PBMC;

D O I：

10.1016/j.jneuroim.2003.11.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Elevated levels of cytokines have been detected in brains of Alzheimer's disease (AD) patients, and altered peripheral levels of IL-1beta, TNFalpha and IL-6 have been reported in these patients. We studied the ability of PBMC from patients with AD, matched with a control group, to release pro- and anti-inflammatory cytokines, and the effect of AChEI treatment on cytokine release. Our data indicates that AChEI treatment down-regulates IL-1, IL-6 and TNF, and up-regulates the expression and production of IL-4 in PBMC in AD patients, and that AChEI leads to the remodelling of the cytokine network, probably acting on the lymphocytic cholinergic system. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：162 / 171

页数：10

共 48 条

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