Comparison of 18F-dopa PET/CT and 123I-MIBG scintigraphy in stage 3 and 4 neuroblastoma: a pilot study

Purpose F-18-Dopa positron emission tomography (PET)/CT has proved a valuable tool for the assessment of neuroendocrine tumours. So far no data are available on F-18-dopa utilization in neuroblastoma (NB). Our aim was to evaluate the role of F-18-dopa PET/CT in NB and compare its diagnostic value with that of I-123-metaiodobenzylguanidine (MIBG) scintigraphy in patients affected by stage 3-4 NB. Methods We prospectively evaluated 28 paired I-123-MIBG and F-18-dopa PET/CT scans in 19 patients: 4 at the time of the NB diagnosis and 15 when NB relapse was suspected. For both imaging modalities we performed a scan-based and a lesion-based analysis and calculated sensitivity, specificity and accuracy. The standard of reference was based on clinical, imaging and histological data. Results NB localizations were confirmed in 17 of 19 patients. F-18-Dopa PET/CT and I-123-MIBG scintigraphy properly detected disease in 16 (94%) and 11 (65%), respectively. On scan-based analysis, F-18-dopa PET/CT showed a sensitivity and accuracy of 95 and 96%, respectively, while I-123-MIBG scanning showed a sensitivity and accuracy of 68 and 64%, respectively (p < 0.05). No significant difference in terms of specificity was found. In 9 of 28 paired scans (32%) PET/CT results influenced the patient management. We identified 156 NB localizations, 141 of which were correctly detected by F-18-dopa PET/CT and 88 by MIBG. On lesion-based analysis, F-18-dopa PET/CT showed a sensitivity and accuracy of 90% whereas I-123-MIBG scintigraphy showed a sensitivity and accuracy of 56 and 57%, respectively (p < 0.001). No significant difference in terms of specificity was found. Conclusion In our NB population F-18-dopa PET/CT displayed higher overall accuracy than I-123-MIBG scintigraphy. Consequently, we suggest F-18-dopa PET/CT as a new opportunity for NB assessment.