Activation of NO donors in mitochondria:: Peroxidase metabolism of (2-hydroxyamino-vinyl)-triphenyl-phosphonium by cytochrome c releases NO and protects cells against apoptosis

被引：19

作者：

Stoyanovsky, Detcho A. ^{[1
]}

Vlasova, Irina I. ^{[2
,3
]}

Belikova, Natalia A. ^{[2
,3
]}

Kapralov, Alexandr ^{[2
,3
]}

Tyurin, Vladimir ^{[2
,3
]}

Kagan, Valerian E. ^{[2
,3
]}

机构：

[1] Univ Pittsburgh, Dept Surg, Pittsburgh, PA 15213 USA

[2] Univ Pittsburgh, Dept Environm & Occupat Hlth, Pittsburgh, PA 15213 USA

[3] Univ Pittsburgh, Ctr Free Radical & Antioxidant Hlth, Pittsburgh, PA 15213 USA

来源：

FEBS LETTERS | 2008年 / 582卷 / 05期

关键词：

nitric oxide; apoptosis; cytochrome c; cardiolipin; hydroxylamine; oxime; triphenylphosphonium;

D O I：

10.1016/j.febslet.2008.01.047

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In mitochondrial apoptosis, the formation of cytochrome c-cardiolipin complex ([CL-cyt c]) with peroxidase properties is an early event in the cascade of reactions that leads to cell death. Herein, we report the synthesis of a new prodrug, (2-hydroxyamino-vinyl)-triphenyl-phosphonium (HVTP), which compartmentalizes exclusively into mitochondria, undergoes a [CL-cyt c]-catalyzed bioactivation to nitric oxide (NO), inhibits peroxidase activity, and protects cells from apoptosis. (c) 2008 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.

引用

页码：725 / 728

页数：4

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