Synthetic Tools that Enable Synthesis and Understanding of Bioactive Macrocycles

被引：0

作者：

Yudin, Andrei K. ^{[1
]}

机构：

[1] Univ Toronto, Davenport Res Labs, 80 St George St, Toronto, ON M6S 3H6, Canada

来源：

SYNLETT | 2022年 / 33卷 / 19期

关键词：

macrocycles; peptides; cellular permeability; heterocycles; amphoteric molecules; CIS-TRANS ISOMERIZATION;

D O I：

10.1055/a-1892-9671

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This article aims to summarizing the evolution of my lab's research efforts in making arid understanding peptide macrocycles. What started as a curiosity-driven investigation of amphoteric structures in multicomponent reactions, has turned into a sustained exploration of complex macrocyclic peptides. As part of this journey, my students and I have introduced new tools that enable chemical synthesis and property-driven optimization of cyclic peptides. These contributions are expected to be relevant in the areas of drug discovery and biological probe design.

引用

页码：1884 / 1889

页数：6

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