Sea urchin embryos as a model system for studying autophagy induced by cadmium stress

被引：38

作者：

Chiarelli, Roberto ^{[1
]}

Agnello, Maria ^{[1
]}

Roccheri, Maria Carmela ^{[1
]}

机构：

[1] Univ Palermo, Sez Biol Cellulare, Dipartimento Sci & Tecnol Mol & Biomol, I-90133 Palermo, Italy

来源：

AUTOPHAGY | 2011年 / 7卷 / 09期

关键词：

autophagy; cadmium; stress; acidic vesicular organelles; bafilomycin A(1); LC3; Paracentrotus lividus embryos; CELL-DEATH; HIGHER EUKARYOTES; APOPTOSIS; TOXICITY; PROTEINS; PATHWAY; MARKER; LC3;

D O I：

10.4161/auto.7.9.16450

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

It is well known that sea urchin embryos are able to activate different defense strategies against stress. We previously demonstrated that cadmium treatment triggers the accumulation of metal in embryonic cells and the activation of defense systems depending on concentration and exposure time, through the synthesis of heat shock proteins and/or the initiation of apoptosis. Here we show that Paracentrotus lividus embryos exposed to Cd adopt autophagy as an additional stratagem to safeguard the developmental program. At present, there are no data focusing on the role of this process in embryo development of marine organisms.

引用

页码：1028 / 1034

页数：7

共 36 条

[1] Cadmium induces an apoptotic response in sea urchin embryos [J].