Adverse Events with the Pfizer-BioNTech COVID-19 Vaccine among Korean Healthcare Workers
被引:13
作者:
Im, Jae Hyoung
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机构:
Inha Univ, Dept Internal Med, Div Infect Dis, Coll Med, 366 Seohaedae Ro, Incheon 22332, South KoreaInha Univ, Dept Internal Med, Div Infect Dis, Coll Med, 366 Seohaedae Ro, Incheon 22332, South Korea
Im, Jae Hyoung
[1
]
Kim, Eunjung
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机构:
Inha Univ Hosp, Infect Control Unit, Incheon, South KoreaInha Univ, Dept Internal Med, Div Infect Dis, Coll Med, 366 Seohaedae Ro, Incheon 22332, South Korea
Kim, Eunjung
[2
]
Lee, Eunyoung
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机构:
Inha Univ Hosp, Infect Control Unit, Incheon, South KoreaInha Univ, Dept Internal Med, Div Infect Dis, Coll Med, 366 Seohaedae Ro, Incheon 22332, South Korea
Lee, Eunyoung
[2
]
Seo, Yeongju
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机构:
Inha Univ Hosp, Infect Control Unit, Incheon, South KoreaInha Univ, Dept Internal Med, Div Infect Dis, Coll Med, 366 Seohaedae Ro, Incheon 22332, South Korea
Seo, Yeongju
[2
]
Lee, Yuran
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机构:
Inha Univ Hosp, Infect Control Unit, Incheon, South KoreaInha Univ, Dept Internal Med, Div Infect Dis, Coll Med, 366 Seohaedae Ro, Incheon 22332, South Korea
Lee, Yuran
[2
]
Jang, Yoonkyoung
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机构:
Inha Univ Hosp, Infect Control Unit, Incheon, South KoreaInha Univ, Dept Internal Med, Div Infect Dis, Coll Med, 366 Seohaedae Ro, Incheon 22332, South Korea
Jang, Yoonkyoung
[2
]
Yu, Soyeon
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机构:
Inha Univ Hosp, Infect Control Unit, Incheon, South KoreaInha Univ, Dept Internal Med, Div Infect Dis, Coll Med, 366 Seohaedae Ro, Incheon 22332, South Korea
Yu, Soyeon
[2
]
Maeng, Yeonju
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机构:
Inha Univ Hosp, Infect Control Unit, Incheon, South KoreaInha Univ, Dept Internal Med, Div Infect Dis, Coll Med, 366 Seohaedae Ro, Incheon 22332, South Korea
Maeng, Yeonju
[2
]
Park, Soyeon
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机构:
Inha Univ Hosp, Infect Control Unit, Incheon, South KoreaInha Univ, Dept Internal Med, Div Infect Dis, Coll Med, 366 Seohaedae Ro, Incheon 22332, South Korea
Park, Soyeon
[2
]
Park, Seohee
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机构:
Inha Univ Hosp, Infect Control Unit, Incheon, South KoreaInha Univ, Dept Internal Med, Div Infect Dis, Coll Med, 366 Seohaedae Ro, Incheon 22332, South Korea
Park, Seohee
[2
]
Kim, Jiah
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机构:
Inha Univ Hosp, Dept Hlth Management, Incheon, South KoreaInha Univ, Dept Internal Med, Div Infect Dis, Coll Med, 366 Seohaedae Ro, Incheon 22332, South Korea
Kim, Jiah
[3
]
Lee, Jin-Soo
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机构:
Inha Univ, Dept Internal Med, Div Infect Dis, Coll Med, 366 Seohaedae Ro, Incheon 22332, South KoreaInha Univ, Dept Internal Med, Div Infect Dis, Coll Med, 366 Seohaedae Ro, Incheon 22332, South Korea
Lee, Jin-Soo
[1
]
Baek, Ji Hyeon
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机构:
Inha Univ, Dept Internal Med, Div Infect Dis, Coll Med, 366 Seohaedae Ro, Incheon 22332, South KoreaInha Univ, Dept Internal Med, Div Infect Dis, Coll Med, 366 Seohaedae Ro, Incheon 22332, South Korea
Baek, Ji Hyeon
[1
]
机构:
[1] Inha Univ, Dept Internal Med, Div Infect Dis, Coll Med, 366 Seohaedae Ro, Incheon 22332, South Korea
[2] Inha Univ Hosp, Infect Control Unit, Incheon, South Korea
[3] Inha Univ Hosp, Dept Hlth Management, Incheon, South Korea
COVID-19;
vaccine;
adverse event;
injection site reaction;
mRNA vaccine;
D O I:
10.3349/ymj.2021.62.12.1162
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
The Pfizer-BioNTech COVID-19 vaccine has shown excellent clinical effectiveness; however, adverse events of the vaccine remain a concern in Korea. We surveyed adverse events in 2498 healthcare workers vaccinated with the Pfizer-BioNTech COVID-19 vaccine at a university hospital. The survey was conducted using a diary card for 7 days following each injection. The questionnaire response rate was 75.1% (1876/2498) for the first dose and 73.8% (1840/2493) for the second dose. Among local reactions, pain was the most commonly reported (84.9% after the first dose and 90.4% after the second dose). After the second dose, two people visited the emergency room due to severe local pain, but no hospitalization or skin necrosis occurred. Among systemic reactions, fatigue was most frequently reported (52.8% after the first dose and 77.0% after the second dose), followed by myalgia (49.0% and 76.1%), headache (28.7% and 59.2%), chills (16.7% and 54.0%), and arthralgia (11.4% and 39.2%). One or more critical adverse events occurred in 0.2% and 0.7% of the vaccinees. Except for urticaria, more adverse events were reported after the second dose than after the first dose. In the future, adverse events should be investigated in older adults, and a future study with a longer observation period should be conducted.
机构:
Tel Aviv Univ, Sackler Sch Med, Tel Aviv, IsraelTel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel
Aharoni, Maayan
Leader, Avi
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h-index: 0
机构:
Tel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel
Rabin Med Ctr, Inst Hematol, 39 Jabotinsky, Tikva, IsraelTel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel
Leader, Avi
Shochat, Tzippy
论文数: 0引用数: 0
h-index: 0
机构:
Rabin Med Ctr, Stat Consulting Unit, Tikva, IsraelTel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel
Shochat, Tzippy
Raanani, Pia
论文数: 0引用数: 0
h-index: 0
机构:
Tel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel
Rabin Med Ctr, Inst Hematol, 39 Jabotinsky, Tikva, IsraelTel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel
Raanani, Pia
Spectre, Galia
论文数: 0引用数: 0
h-index: 0
机构:
Tel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel
Rabin Med Ctr, Inst Hematol, 39 Jabotinsky, Tikva, IsraelTel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel
机构:
Penn State Hlth Milton S Hershey Med Ctr, Dept Med, Div Internal Med, 500 Univ Dr, Hershey, PA 17033 USAPenn State Hlth Milton S Hershey Med Ctr, Dept Med, Div Internal Med, 500 Univ Dr, Hershey, PA 17033 USA
Hajduczok, Alexander G.
DiJoseph, Kara M.
论文数: 0引用数: 0
h-index: 0
机构:
Penn State Hlth Milton S Hershey Med Ctr, Dept Med, Div Internal Med, 500 Univ Dr, Hershey, PA 17033 USAPenn State Hlth Milton S Hershey Med Ctr, Dept Med, Div Internal Med, 500 Univ Dr, Hershey, PA 17033 USA
DiJoseph, Kara M.
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h-index:
机构:
Bent, Brinnae
Thorp, Audrey K.
论文数: 0引用数: 0
h-index: 0
机构:
Penn State Hlth Milton S Hershey Med Ctr, Dept Med, Div Internal Med, 500 Univ Dr, Hershey, PA 17033 USAPenn State Hlth Milton S Hershey Med Ctr, Dept Med, Div Internal Med, 500 Univ Dr, Hershey, PA 17033 USA
Thorp, Audrey K.
Mullholand, Jon B.
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h-index: 0
机构:
Penn State Hlth Milton S Hershey Med Ctr, Dept Med, Div Internal Med, 500 Univ Dr, Hershey, PA 17033 USAPenn State Hlth Milton S Hershey Med Ctr, Dept Med, Div Internal Med, 500 Univ Dr, Hershey, PA 17033 USA
Mullholand, Jon B.
MacKay, Stuart A.
论文数: 0引用数: 0
h-index: 0
机构:
Penn State Hlth Milton S Hershey Med Ctr, Dept Med, Div Internal Med, 500 Univ Dr, Hershey, PA 17033 USAPenn State Hlth Milton S Hershey Med Ctr, Dept Med, Div Internal Med, 500 Univ Dr, Hershey, PA 17033 USA
MacKay, Stuart A.
Barik, Sabrina
论文数: 0引用数: 0
h-index: 0
机构:
Penn State Hlth Milton S Hershey Med Ctr, Dept Med, Div Internal Med, 500 Univ Dr, Hershey, PA 17033 USAPenn State Hlth Milton S Hershey Med Ctr, Dept Med, Div Internal Med, 500 Univ Dr, Hershey, PA 17033 USA
Barik, Sabrina
Coleman, Jamie J.
论文数: 0引用数: 0
h-index: 0
机构:
Denver Hlth Med Ctr, Dept Surg, Denver, CO USAPenn State Hlth Milton S Hershey Med Ctr, Dept Med, Div Internal Med, 500 Univ Dr, Hershey, PA 17033 USA
Coleman, Jamie J.
Paules, Catharine, I
论文数: 0引用数: 0
h-index: 0
机构:
Penn State Hlth Milton S Hershey Med Ctr, Dept Med, Div Infect Dis, Hershey, PA USAPenn State Hlth Milton S Hershey Med Ctr, Dept Med, Div Internal Med, 500 Univ Dr, Hershey, PA 17033 USA
Paules, Catharine, I
Tinsley, Andrew
论文数: 0引用数: 0
h-index: 0
机构:
Penn State Hlth Milton S Hershey Med Ctr, Dept Med, Div Gastroenterol, Hershey, PA USAPenn State Hlth Milton S Hershey Med Ctr, Dept Med, Div Internal Med, 500 Univ Dr, Hershey, PA 17033 USA
机构:
Tel Aviv Univ, Sackler Sch Med, Tel Aviv, IsraelTel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel
Aharoni, Maayan
Leader, Avi
论文数: 0引用数: 0
h-index: 0
机构:
Tel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel
Rabin Med Ctr, Inst Hematol, 39 Jabotinsky, Tikva, IsraelTel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel
Leader, Avi
Shochat, Tzippy
论文数: 0引用数: 0
h-index: 0
机构:
Rabin Med Ctr, Stat Consulting Unit, Tikva, IsraelTel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel
Shochat, Tzippy
Raanani, Pia
论文数: 0引用数: 0
h-index: 0
机构:
Tel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel
Rabin Med Ctr, Inst Hematol, 39 Jabotinsky, Tikva, IsraelTel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel
Raanani, Pia
Spectre, Galia
论文数: 0引用数: 0
h-index: 0
机构:
Tel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel
Rabin Med Ctr, Inst Hematol, 39 Jabotinsky, Tikva, IsraelTel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel
机构:
Penn State Hlth Milton S Hershey Med Ctr, Dept Med, Div Internal Med, 500 Univ Dr, Hershey, PA 17033 USAPenn State Hlth Milton S Hershey Med Ctr, Dept Med, Div Internal Med, 500 Univ Dr, Hershey, PA 17033 USA
Hajduczok, Alexander G.
DiJoseph, Kara M.
论文数: 0引用数: 0
h-index: 0
机构:
Penn State Hlth Milton S Hershey Med Ctr, Dept Med, Div Internal Med, 500 Univ Dr, Hershey, PA 17033 USAPenn State Hlth Milton S Hershey Med Ctr, Dept Med, Div Internal Med, 500 Univ Dr, Hershey, PA 17033 USA
DiJoseph, Kara M.
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h-index:
机构:
Bent, Brinnae
Thorp, Audrey K.
论文数: 0引用数: 0
h-index: 0
机构:
Penn State Hlth Milton S Hershey Med Ctr, Dept Med, Div Internal Med, 500 Univ Dr, Hershey, PA 17033 USAPenn State Hlth Milton S Hershey Med Ctr, Dept Med, Div Internal Med, 500 Univ Dr, Hershey, PA 17033 USA
Thorp, Audrey K.
Mullholand, Jon B.
论文数: 0引用数: 0
h-index: 0
机构:
Penn State Hlth Milton S Hershey Med Ctr, Dept Med, Div Internal Med, 500 Univ Dr, Hershey, PA 17033 USAPenn State Hlth Milton S Hershey Med Ctr, Dept Med, Div Internal Med, 500 Univ Dr, Hershey, PA 17033 USA
Mullholand, Jon B.
MacKay, Stuart A.
论文数: 0引用数: 0
h-index: 0
机构:
Penn State Hlth Milton S Hershey Med Ctr, Dept Med, Div Internal Med, 500 Univ Dr, Hershey, PA 17033 USAPenn State Hlth Milton S Hershey Med Ctr, Dept Med, Div Internal Med, 500 Univ Dr, Hershey, PA 17033 USA
MacKay, Stuart A.
Barik, Sabrina
论文数: 0引用数: 0
h-index: 0
机构:
Penn State Hlth Milton S Hershey Med Ctr, Dept Med, Div Internal Med, 500 Univ Dr, Hershey, PA 17033 USAPenn State Hlth Milton S Hershey Med Ctr, Dept Med, Div Internal Med, 500 Univ Dr, Hershey, PA 17033 USA
Barik, Sabrina
Coleman, Jamie J.
论文数: 0引用数: 0
h-index: 0
机构:
Denver Hlth Med Ctr, Dept Surg, Denver, CO USAPenn State Hlth Milton S Hershey Med Ctr, Dept Med, Div Internal Med, 500 Univ Dr, Hershey, PA 17033 USA
Coleman, Jamie J.
Paules, Catharine, I
论文数: 0引用数: 0
h-index: 0
机构:
Penn State Hlth Milton S Hershey Med Ctr, Dept Med, Div Infect Dis, Hershey, PA USAPenn State Hlth Milton S Hershey Med Ctr, Dept Med, Div Internal Med, 500 Univ Dr, Hershey, PA 17033 USA
Paules, Catharine, I
Tinsley, Andrew
论文数: 0引用数: 0
h-index: 0
机构:
Penn State Hlth Milton S Hershey Med Ctr, Dept Med, Div Gastroenterol, Hershey, PA USAPenn State Hlth Milton S Hershey Med Ctr, Dept Med, Div Internal Med, 500 Univ Dr, Hershey, PA 17033 USA