Tocilizumab treatment for new onset refractory status epilepticus

被引：151

作者：

Jun, Jin-Sun ^{[1
]}

Lee, Soon-Tae ^{[2
]}

Kim, Ryul ^{[2
]}

Chu, Kon ^{[2
]}

Lee, Sang Kun ^{[2
]}

机构：

[1] Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Neurol, Daegu, South Korea

[2] Seoul Natl Univ Hosp, Dept Neurol, 101 Daehak Ro, Seoul 03080, South Korea

来源：

ANNALS OF NEUROLOGY | 2018年 / 84卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

RITUXIMAB; THERAPY;

D O I：

10.1002/ana.25374

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We investigated the therapeutic potential of the interleukin-6 receptor inhibitor tocilizumab in 7 patients with new onset refractory status epilepticus (NORSE) who remained refractory to conventional immunotherapy with rituximab (n = 5) or without rituximab (n = 2). Status epilepticus (SE) was terminated after 1 or 2 doses of tocilizumab in 6 patients with a median interval of 3 days from the initiation. They had no recurrence of SE during the observation. However, 2 patients experienced severe adverse events related to infection during the tocilizumab therapy. Further prospective controlled studies are warranted to validate the efficacy and safety of tocilizumab in patients with NORSE.

引用

页码：940 / 945

页数：6

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