OX40 Ligand Levels and High-sensitivity C-reactive Protein Levels in Blood from Local Coronary Plaque and the Femoral Artery in Patients with Acute Coronary Syndrome or Stable Angina

被引：12
作者：
Shi, J. Z. [1 ]
Wang, L. Y. [1 ]
Zhu, Y. [1 ]
Zhao, C. Y. [1 ]
Liu, W. [1 ]
Jiang, S. L. [1 ]
You, H. W. [1 ]
Wang, Y. [1 ]
Xu, F. Y. [1 ]
Tang, Y. S. [1 ]
Cui, L. Q. [1 ]
机构：
[1] Shandong Univ, Prov Hosp, Dept Cardiol, Jinan 250021, Shandong, Peoples R China
来源：
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2011年 / 39卷 / 04期
关键词：
ACUTE CORONARY SYNDROME; CORONARY PLAQUE; OX40; LIGAND; HIGH SENSITIVITY; C-REACTIVE PROTEIN; FIBRINOGEN; T-CELLS; ATHEROSCLEROSIS; DISEASE; IDENTIFICATION; ATHEROGENESIS; AMELIORATION; INFLAMMATION; MOLECULE; SERUM; RISK;
D O I：
10.1177/147323001103900415
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
OX40 ligand (OX40L) and high-sensitivity C-reactive protein (hs-CRP) play important roles in the pathogenesis of atherosclerosis. In this study, consecutive patients with acute coronary syndrome (ACS; n = 90) or stable angina (SA; n = 40) and healthy control subjects (n = 50) were evaluated to assess plasma OX40L and serum hs-CRP levels in local coronary plaque and the femoral artery. OX40L and hs-CRP levels in the femoral artery were significantly higher in patients with ACS compared with controls. OX40L and hs-CRP levels in local coronary plaque (OX40L(c) and hs-CRP, respectively) were significantly higher in ACS than in SA patients. OX40L and hs-CRP levels were positively correlated with each other and were also correlated with fibrinogen levels. The number of complex lesions was correlated with OX40L(c) and hs-CRP, levels. It is concluded that the OX40L(c) level was highly sensitive for evaluating the inflammatory response in ACS and elevated levels of OX4OL(c) may be a valuable predictive marker for increased risk of atherosclerotic progression in ACS patients.
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收藏
页码：1275 / 1283
页数：9
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