OX40 Ligand Levels and High-sensitivity C-reactive Protein Levels in Blood from Local Coronary Plaque and the Femoral Artery in Patients with Acute Coronary Syndrome or Stable Angina

被引：12

作者：

Shi, J. Z. ^{[1
]}

Wang, L. Y. ^{[1
]}

Zhu, Y. ^{[1
]}

Zhao, C. Y. ^{[1
]}

Liu, W. ^{[1
]}

Jiang, S. L. ^{[1
]}

You, H. W. ^{[1
]}

Wang, Y. ^{[1
]}

Xu, F. Y. ^{[1
]}

Tang, Y. S. ^{[1
]}

Cui, L. Q. ^{[1
]}

机构：

[1] Shandong Univ, Prov Hosp, Dept Cardiol, Jinan 250021, Shandong, Peoples R China

来源：

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2011年 / 39卷 / 04期

关键词：

ACUTE CORONARY SYNDROME; CORONARY PLAQUE; OX40; LIGAND; HIGH SENSITIVITY; C-REACTIVE PROTEIN; FIBRINOGEN; T-CELLS; ATHEROSCLEROSIS; DISEASE; IDENTIFICATION; ATHEROGENESIS; AMELIORATION; INFLAMMATION; MOLECULE; SERUM; RISK;

D O I：

10.1177/147323001103900415

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

OX40 ligand (OX40L) and high-sensitivity C-reactive protein (hs-CRP) play important roles in the pathogenesis of atherosclerosis. In this study, consecutive patients with acute coronary syndrome (ACS; n = 90) or stable angina (SA; n = 40) and healthy control subjects (n = 50) were evaluated to assess plasma OX40L and serum hs-CRP levels in local coronary plaque and the femoral artery. OX40L and hs-CRP levels in the femoral artery were significantly higher in patients with ACS compared with controls. OX40L and hs-CRP levels in local coronary plaque (OX40L(c) and hs-CRP, respectively) were significantly higher in ACS than in SA patients. OX40L and hs-CRP levels were positively correlated with each other and were also correlated with fibrinogen levels. The number of complex lesions was correlated with OX40L(c) and hs-CRP, levels. It is concluded that the OX40L(c) level was highly sensitive for evaluating the inflammatory response in ACS and elevated levels of OX4OL(c) may be a valuable predictive marker for increased risk of atherosclerotic progression in ACS patients.

引用

页码：1275 / 1283

页数：9

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