The Potential Role of Pro-Inflammatory and Anti-Inflammatory Cy-tokines in Epilepsy Pathogenesis

被引：55

作者：

Kamali, Ali N. ^{[1
,2
]}

Zian, Zeineb ^{[3
]}

Bautista, Jose M. ^{[4
,5
]}

Hamedifar, Haleh ^{[1
,2
]}

Hossein-Khannazer, Nikoo ^{[6
,7
]}

Hosseinzadeh, Ramin ^{[8
]}

Yazdani, Reza ^{[9
]}

Azizi, Gholamreza ^{[10
]}

机构：

[1] Alborz Univ Med Sci, CinnaGen Med Biotechnol Res Ctr, Karaj, Iran

[2] CinnaGen Res & Prod Co, Alborz, Iran

[3] Univ Abdelmalek Essaadi, Fac Sci & Tech Tangier, Biomed Genom & Oncogenet Res Lab, Tetouan, Morocco

[4] Univ Complutense Madrid, Fac Vet Sci, Dept Biochem & Mol Biol, Madrid 28040, Spain

[5] Res Inst Hosp 12 Octubre, Madrid 28041, Spain

[6] Shahid Beheshti Univ Med Sci, Sch Med, Dept Immunol, Tehran, Iran

[7] Shahid Beheshti Univ Med Sci, Gastroenterol & Liver Dis Res Ctr, Res Inst Gastroenterol & Liver Dis, Tehran, Iran

[8] Univ Tehran Med Sci, Sch Med, Dept Med Immunol, Tehran, Iran

[9] Univ Tehran Med Sci, Res Ctr Immunodeficiencies, Childrens Med Ctr, Tehran, Iran

[10] Alborz Univ Med Sci, Noncommunicable Dis Res Ctr, Karaj, Iran

来源：

ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS | 2021年 / 21卷 / 10期

关键词：

Epilepsy; seizure; neuroinflammation; pro-inflammatory mediators; cytokine; BLOOD-BRAIN-BARRIER; NECROSIS-FACTOR-ALPHA; INTERLEUKIN-6; GENE-EXPRESSION; INCREASED PLASMA-LEVELS; CENTRAL-NERVOUS-SYSTEM; NITRIC-OXIDE SYNTHASE; NF-KAPPA-B; TNF-ALPHA; CEREBROSPINAL-FLUID; STATUS EPILEPTICUS;

D O I：

10.2174/1871530320999201116200940

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Within the pathophysiology of epilepsy, as a chronic brain disorder, the involvement of neuroinflammation has been extensively implied. Recurrent seizures of epilepsy have been associated with elevated levels of immune mediators that seem to play a pivotal role in triggering them. Neurons, glia, and endothelial cells of the blood-brain barrier (BBB) take part in such inflammatory processes by expressing receptors of associated mediators through autocrine and paracrine stimulation of intracellular signaling pathways. In this milieu, elevated cytokine levels in serum and brain tissue have been reported in patients with an epileptic profile. Noteworthy, interleukin (IL)-113, IL-6, and tumor necrosis factor-alpha (TNF-alpha) are the proinflammatory cytokines mostly associated, in literature, with the pathogenesis of epilepsies. In this review, we examine the function of these cytokines in connection with transforming growth factor-beta (TGF-13), IL-8, IL-12, IL-18, and macrophage inflammatory protein (MIP) as potential proinflammatory mediators in the neuropathology of epilepsy.

引用

页码：1760 / 1774

页数：15

共 151 条

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