Chronic Myeloid Leukemia in a Patient with Previous Idiopathic Thrombocytopenic Purpura: How to Manage Imatinib Together with Eltrombopag

被引:1
作者
Autore, Francesco [1 ]
Sora', Federica [1 ,2 ]
Chiusolo, Patrizia [1 ,2 ]
Minnella, Gessica [1 ]
Colangelo, Maria [3 ]
Rossi, Elena [1 ,2 ]
Sica, Simona [1 ,2 ]
机构
[1] Fdn Policlin Univ A Gemelli IRCCS, Dipartimento Diagnost Immagini Radioterapia Oncol, I-00168 Rome, Italy
[2] Univ Cattolica Sacro Cuore, Sez Ematol, Dipartimento Sci Radiol & Ematol, I-00168 Rome, Italy
[3] Fdn Policlin Univ A Gemelli IRCCS, UOC Genet Med, I-00168 Rome, Italy
来源
MEDICINA-LITHUANIA | 2021年 / 57卷 / 12期
关键词
chronic myeloid-leukemia; idiopathic thrombocytopenic purpura; eltrombopag; imatinib;
D O I
10.3390/medicina57121326
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The occurrence of chronic myeloid leukemia (CML), or other myeloproliferative diseases, after the development of idiopathic thrombocytopenic purpura (ITP) is very rare in the current medical literature. Considering the advances in ITP management, and the wide use of new drugs for ITP and CML, we report an unusual case with this association. Our case report focused on a 64-year-old man with long-standing ITP treated with eltrombopag, who developed hyperleukocytosis during follow-up; after specific laboratory exams, it was diagnosed as CML and he began treatment with imatinib. The treatment with eltrombopag was balanced with imatinib to stabilize his platelet count. Data on bcr-abl and JAK2 transcripts were collected and revealed an optimal response with the achievement of negativization of both molecular signatures. We could demonstrate that treatment with imatinib and eltrombopag was well tolerated and allowed complete molecular remission of CML to be achieved, as well as of ITP.
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页数:5
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