Hypotensive effect and tissue distribution of the dinitrosyl iron complexes, a nitric oxide donor

被引：10

作者：

Manukhina, EB

Malyshev, IY

Malenyuk, EB

Zenina, TA

Podkidyshev, DA

Mikoyan, VD

Kubrina, LN

Vanin, AF

机构：

[1] Russian Acad Med Sci, Inst Gen pathol & Pathophysiol, Moscow, Russia

[2] Russian Acad Sci, Inst Chem Phys, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1998年 / 125卷 / 01期

基金：

俄罗斯基础研究基金会;

关键词：

dinitrosyl iron complexes; nitric oxide; tissue distribution; arterial pressure;

D O I：

10.1007/BF02496792

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Hypotensive effect of the dinitrosyl iron complexes, an NO donor, is compared with distribution of these complexes in organs and tissues after their intravenous administration to wakeful animals. Hypotensive effect of iron complexes depended on dose and postinjection time. There was a strong correlation between hypotensive effect and the content of dinitrosyl iron complex in the studied organs. Effective dose of dinitrosyl iron complexes that did not provoke adverse effects was about 200 mg/kg. This preparation is a prospective source of NO to treat and prevent pathological states related to NO deficiency.

引用

页码：23 / 25

页数：3