A Novel Nomogram Integrated with Inflammation-Based Factors to Predict the Prognosis of Gastric Cancer Patients

被引:14
作者
Wang, Xueping [1 ]
Mao, Minjie [1 ]
Zhu, Shihao [2 ,3 ]
Xing, Shan [1 ]
Song, Yiling [1 ]
Zhang, Lin [1 ]
Chi, Peidong [1 ]
机构
[1] Sun Yat Sen Univ, Ctr Canc, Dept Lab Med, Collaborat Innovat Ctr Canc Med,State Key Lab Onc, Guangzhou, Peoples R China
[2] Chinese Acad Med Sci, Canc Hosp, Natl Canc Ctr, Dept Etiol & Carcinogenesis, Beijing 100021, Peoples R China
[3] Peking Union Med Coll, Beijing 100021, Peoples R China
关键词
Gastric cancer; Inflammation factors; Nomogram; Prognosis; C-REACTIVE PROTEIN; SURVIVAL; MARKERS;
D O I
10.1007/s12325-020-01356-4
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Introduction Gastric cancer (GC) is the fifth most common cancer worldwide, and every year approximately 950,000 individuals are diagnosed worldwide. Our study aimed to establish an effective nomogram to predict the prognosis of GC based on inflammation biomarkers. Methods We retrospectively analysed GC patients from the Sun Yat-sen University Cancer Center. The nomogram was developed with a primary cohort (n = 1067), and 537 patients were included in the validation cohort. The univariate survival analyses included 19 biomarkers. Results The multivariate analysis showed that tumour stage, metastasis stage and C-reactive protein (CRP), albumin (ALB), carcinoembryonic antigen (CEA) and carbohydrate antigen-199 (CA199) levels as well as the lymphocyte (LYM) count were independent risk factors for the prognosis of GC patients. The nomogram was based on the above factors. In the primary cohort, the nomogram had a concordance index (C-index) of 0.825 (95% CI 0.796-0.854), which was higher than the C-index of the AJCC TNM stage and that of the other biomarkers (CEA and CA199). The calibration plot suggested good agreement between the actual and nomogram-predicted overall survival (OS) probabilities, and the decision curve analyses showed that the nomogram model had a higher overall net benefit in predicting OS than the AJCC TNM stage. Moreover, we divided the patients into the following three distinct risk groups for OS based on the nomogram points: low, middle and high risk. The differences in OS rates were significant among the subgroups (P < 0.001). Conclusion A novel nomogram integrated with inflammatory prognostic factors was proposed, which is highly predictive of OS in GC patients.
引用
收藏
页码:2902 / 2915
页数:14
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