Effects of thalamic deep brain stimulation on spontaneous language production

被引：10

作者：

Ehlen, Felicitas ^{[1
]}

Vonberg, Isabelle ^{[1
]}

Kuehn, Andrea A. ^{[2
]}

Klostermann, Fabian ^{[1
]}

机构：

[1] Charite Univ Med Berlin, Dept Neurol, Motor & Cognit Grp, Campus Benjamin Franklin,Hindenburgdamm 30, D-12203 Berlin, Germany

[2] Charite Univ Med Berlin, Dept Neurol, Motor Neurosci Grp, Campus Virchow Klinikum, Augustenburger Pl 1, D-13353 Berlin, Germany

来源：

NEUROPSYCHOLOGIA | 2016年 / 89卷

关键词：

VIM-DBS; Thalamus; Spontaneous language; Syntax; SUBTHALAMIC NUCLEUS STIMULATION; CHRONIC ELECTRICAL-STIMULATION; VERBAL WORKING-MEMORY; ESSENTIAL TREMOR; PARKINSONS-DISEASE; BASAL GANGLIA; COGNITIVE DEFICITS; DIFFERENTIAL IMPACT; OBJECT ACTIVATION; SEMANTIC MEMORY;

D O I：

10.1016/j.neuropsychologia.2016.05.028

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The thalamus is thought to contribute to language-related processing, but specifications of this notion remain vague. An assessment of potential effects of thalamic deep brain stimulation (DBS) on spontaneous language may help to delineate respective functions. For this purpose, we analyzed spontaneous language samples from thirteen (six female / seven male) patients with essential tremor treated with DBS of the thalamic ventral intermediate nucleus (VIM) in their respective ON vs. OFF conditions. Samples were obtained from semi-structured interviews and examined on multidimensional linguistic levels. In the VIM-DBS ON condition, participants used a significantly higher proportion of paratactic as opposed to hypotactic sentence structures. This increase correlated negatively with the change in the more global cognitive score, which in itself did not change significantly. In conclusion, VIM-DBS appears to induce the use of a simplified syntactic structure. The findings are discussed in relation to concepts of thalamic roles in language-related cognitive behavior. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：74 / 82

页数：9

共 123 条

[41] The roles of sequencing and verbal working memory in sentence comprehension deficits in Parkinson's disease [J].

Hochstadt, Jesse ;

Nakano, Hiroko ;

Lieberman, Philip ;

Friedman, Joseph .

BRAIN AND LANGUAGE, 2006, 97 (03) :243-257

[42] Modulation of cortical neural dynamics during thalamic deep brain stimulation in patients with essential tremor [J].

Hohlefeld, Friederike U. ;

Ehlen, Felicitas ;

Krugel, Lea K. ;

Kuehn, Andrea A. ;

Curio, Gabriel ;

Klostermann, Fabian ;

Nikulin, Vadim V. .

NEUROREPORT, 2013, 24 (13) :751-756

[43] Linguistic correlates of asymmetric motor symptom severity in Parkinson's Disease [J].

Holtgraves, Thomas ;

McNamara, Patrick ;

Cappaert, Kevin ;

Durso, Raymond .

BRAIN AND COGNITION, 2010, 72 (02) :189-196

[44]

Hugdahl K, 1997, NEUROPSY NEUROPSY BE, V10, P155

[45] Computer-assisted analysis of spontaneous speech: quantification of basic parameters in aphasic and unimpaired language [J].

Hussmann, Katja ;

Grande, Marion ;

Meffert, Elisabeth ;

Christoph, Swetlana ;

Piefke, Martina ;

Willmes, Klaus ;

Huber, Walter .

CLINICAL LINGUISTICS & PHONETICS, 2012, 26 (08) :661-680

[46] LANGUAGE PRODUCTION IN PARKINSONS-DISEASE - ACOUSTIC AND LINGUISTIC CONSIDERATIONS [J].

ILLES, J ;

METTER, EJ ;

HANSON, WR ;

IRITANI, S .

BRAIN AND LANGUAGE, 1988, 33 (01) :146-160

[47] Studies in Language Behavior [J].

Johnson, Wendell .

PSYCHOLOGICAL MONOGRAPHS, 1944, 56 (02) :1-111

[48] Screening for cognitive deficits in Parkinson's disease with the Parkinson neuropsychometric dementia assessment (PANDA) instrument [J].

Kalbe, Elke ;

Calabrese, Pasquale ;

Kohn, Nils ;

Hilker, Ruediger ;

Riedel, Oliver ;

Wittchen, Hans-Ulrich ;

Dodel, Richard ;

Otto, Joerg ;

Ebersbach, Georg ;

Kessler, Josef .

PARKINSONISM & RELATED DISORDERS, 2008, 14 (02) :93-101

[49]

Keller J., GRAMMATISCHE STRUKTU

[50] ON THE PRESERVATION OF SYNTAX IN ALZHEIMERS-DISEASE - EVIDENCE FROM WRITTEN SENTENCES [J].

KEMPER, S ;

LABARGE, E ;

FERRARO, FR ;

CHEUNG, HT ;

CHEUNG, H ;

STORANDT, M .

ARCHIVES OF NEUROLOGY, 1993, 50 (01) :81-86

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