Organocatalysis - Organocatalysis lost: Modern chemistry, ancient chemistry, and an unseen biosynthetic apparatus

被引：457

作者：

Barbas, Carlos F., III ^{[1
,2
,3
]}

机构：

[1] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[3] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 01期

关键词：

aldolases; asymmetric synthesis; biosynthesis; catalytic antibodies; organocatalysis;

D O I：

10.1002/anie.200702210

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) One enigma leads in three directions: The Hajos-Wiechert reaction presented an enigma that went unsolved for three decades. With the unravelling of this enigma, organocatalysis plays a major role in the development of efficient catalytic asymmetric methodologies. The mechanisms of organocatalysis also shed light on the origin of homochirality essential for life and provide clues to yet-to-be-discovered biosynthetic mechanisms at work in living organisms today. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：42 / 47

页数：6

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