Itch and Mental Health in Dermatological Patients across Europe: A Cross-Sectional Study in 13 Countries

被引:53
作者
Dalgard, Florence J. [1 ,2 ]
Svensson, Ake [1 ]
Halvorsen, Jon Anders [3 ]
Gieler, Uwe [4 ,5 ]
Schut, Christina [6 ]
Tomas-Aragones, Lucia [7 ]
Lien, Lars [2 ]
Poot, Francoise [8 ]
Jemec, Gregor B. E. [9 ,10 ]
Misery, Laurent [11 ]
Szabo, Csanad [12 ]
Linder, Dennis [13 ]
Sampogna, Francesca [14 ]
Spillekom-van Koulil, Saskia [15 ]
Balieva, Flora [16 ]
Szepietowski, Jacek C. [17 ]
Lvov, Andrey [18 ]
Marron, Servando E. [19 ]
Altunay, Ilknur K. [20 ]
Finlay, Andrew Y. [21 ]
Salek, Sam [22 ]
Kupfer, Jorg [5 ]
机构
[1] Lund Univ, Skane Univ Hosp, Dept Dermatol & Venereol, SE-20502 Malmo, Sweden
[2] Hosp Innlandet Trust, Norwegian Natl Advisory Unit Concurrent Subst Abu, Brumundal, Norway
[3] Oslo Univ Hosp, Dept Dermatol, Oslo, Norway
[4] Justus Liebig Univ, Dept Dermatol, Giessen, Germany
[5] Rumailah Hosp, Hamad Med Corp Doha, Dept Dermatol, Doha, Qatar
[6] Justus Liebig Univ, Inst Med Psychol, Giessen, Germany
[7] Univ Zaragoza, Dept Psychol, Zaragoza, Spain
[8] Univ Libre Bruxelles, Dept Dermatol, Brussels, Belgium
[9] Zealand Univ Hosp, Dept Dermatol, Roskilde, Denmark
[10] Univ Copenhagen, Hlth Sci Fac, Copenhagen, Denmark
[11] Univ Hosp Brest, Dept Dermatol, Brest, France
[12] Univ Szeged, Dept Dermatol & Allergol, Szeged, Hungary
[13] Ben Gurion Univ Negev, Beer Sheva, Israel
[14] IRCCS, IDI, Clin Epidemiol Unit, Rome, Italy
[15] Radbout Univ, Med Ctr, Dept Med Psychol, Radbout Inst Hlth Sci, Nijmegen, Netherlands
[16] Stavanger Univ Hosp, Dept Dermatol, Stavanger, Norway
[17] Wroclaw Med Univ, Dept Dermatol, Wroclaw, Poland
[18] Moscow Sci & Pract Ctr Dermatovenereol & Cosmetol, Moscow, Russia
[19] Royo Villanova Hosp, Dept Dermatol, Zaragoza, Spain
[20] Univ Hlth Sci, Istanbul Sisli Hamidiye Etfal Training & Res Hosp, Dept Dermatol & Venereol, Istanbul, Turkey
[21] Cardiff Univ, Sch Med, Dept Dermatol, Cardiff, Wales
[22] Univ Hertfordshire, Sch Life & Med Sci, Inst Med Dev, Hatfield, Herts, England
关键词
QUALITY-OF-LIFE; FINANCIAL DIFFICULTIES; HEMODIALYSIS-PATIENTS; HOSPITAL ANXIETY; CHRONIC PRURITUS; DEPRESSION; SEVERITY; ASSOCIATION; SKIN; EPIDEMIOLOGY;
D O I
10.1016/j.jid.2019.05.034
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Itch is a highly prevalent and multidimensional symptom. We aimed to analyze the association between itch and mental health in dermatological patients. This multicenter study is observational and cross-sectional and was conducted in dermatological clinics across 13 European countries. A total of 3,530 patients and 1,094 healthy controls were included. Patients were examined clinically. Outcome measures were itch (presence, chronicity, and intensity), the Hospital Anxiety and Depression Scale, EQ-5D visual analogue scale, sociodemographics, suicidal ideation, and stress (negative life events and economic difficulties). Ethical approval was obtained. Results showed significant association between the presence of itch in patients and clinical depression (odds ratio, 1.53; 95% confidence interval, 1.15-2.02), suicidal ideation (odds ratio, 1.27; 95% confidence interval, 1.01-1.60), and economic difficulties (odds ratio, 1.24; 95% confidence interval, 1.10e1.50). The mean score of reported generic health status assessed by the EQ-5D visual analogue scale was 65.9 (standard deviation = 20.1) in patients with itch, compared with 74.7 (standard deviation = 18.0) in patients without itch (P < 0.001) and 74.9 (standard deviation = 15.7) in controls with itch compared with 82.9 (standard deviation = 15.6) in controls without itch (P < 0.001). Itch contributes substantially to the psychological disease burden in dermatological patients, and the management of patients should include access to multidisciplinary care.
引用
收藏
页码:568 / 573
页数:6
相关论文
共 41 条
[1]   The burden of common skin diseases assessed with the EQ5D: a European multicentre study in 13 countries [J].
Balieva, F. ;
Kupfer, J. ;
Lien, L. ;
Gieler, U. ;
Finlay, A. Y. ;
Tomas-Aragones, L. ;
Poot, F. ;
Misery, L. ;
Sampogna, F. ;
van Middendorp, H. ;
Halvorsen, J. A. ;
Szepietowski, J. C. ;
Lvov, A. ;
Marron, S. E. ;
Salek, M. S. ;
Dalgard, F. J. .
BRITISH JOURNAL OF DERMATOLOGY, 2017, 176 (05) :1170-1178
[2]   The validity of the Hospital Anxiety and Depression Scale - An updated literature review [J].
Bjelland, I ;
Dahl, AA ;
Haug, TT ;
Neckelmann, D .
JOURNAL OF PSYCHOSOMATIC RESEARCH, 2002, 52 (02) :69-77
[3]   Anxiety, depression and impaired health-related quality of life in patients with occupational hand eczema [J].
Boehm, Dana ;
Schmid-Ott, Gerhard ;
Finkeldey, Florence ;
John, Swen Malte ;
Dwinger, Christine ;
Werfel, Thomas ;
Diepgen, Thomas L. ;
Breuer, Kristine .
CONTACT DERMATITIS, 2012, 67 (04) :184-192
[4]   The self-assessed psychological comorbidities of prurigo in European patients: a multicentre study in 13 countries [J].
Brenaut, E. ;
Halvorsen, J. A. ;
Dalgard, F. J. ;
Lien, L. ;
Balieva, F. ;
Sampogna, F. ;
Linder, D. ;
Evers, A. W. M. ;
Jemec, G. B. E. ;
Gieler, U. ;
Szepietowski, J. ;
Poot, F. ;
Altunay, I. K. ;
Finlay, A. Y. ;
Salek, S. S. ;
Szabo, C. ;
Lvov, A. ;
Marron, S. E. ;
Tomas-Aragones, L. ;
Kupfer, J. ;
Misery, L. .
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2019, 33 (01) :157-162
[5]  
Caccavale S, 2016, GIORN ITAL DERMAT V, V151, P525
[6]   Skin neurogenic inflammation [J].
Choi, Jae Eun ;
Di Nardo, Anna .
SEMINARS IN IMMUNOPATHOLOGY, 2018, 40 (03) :249-259
[7]   Relationship between itch and psychological status of patients with atopic dermatitis [J].
Chrostowska-Plak, D. ;
Reich, A. ;
Szepietowski, J. C. .
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2013, 27 (02) :E239-E242
[8]   A comparative review of generic quality-of-life instruments [J].
Coons, SJ ;
Rao, S ;
Keininger, DL ;
Hays, RD .
PHARMACOECONOMICS, 2000, 17 (01) :13-35
[9]   Itch in the community: associations with psychosocial factors among adults [J].
Dalgard, F. ;
Lien, L. ;
Dalen, I. .
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2007, 21 (09) :1215-1219
[10]   Self-reported skin morbidity among adults:: Associations with quality of life and general health in a Norwegian survey [J].
Dalgard, F ;
Svensson, Å ;
Holm, JO ;
Sundby, J .
JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS, 2004, 9 (02) :120-125