SARS-CoV-2 infection, antibody positivity and seroconversion rates in staff and students following full reopening of secondary schools in England: A prospective cohort study, September-December 2020

被引：16

作者：

Ladhani, Shamez N. ^{[1
,2
]}

Ireland, Georgina ^{[1
]}

Baawuah, Frances ^{[1
]}

Beckmann, Joanne ^{[3
]}

Okike, Ifeanyichukwu O. ^{[1
,4
,5
]}

Ahmad, Shazaad ^{[6
]}

Garstang, Joanna ^{[7
]}

Brent, Andrew J. ^{[8
,9
]}

Brent, Bernadette ^{[7
]}

Walker, Jemma ^{[1
]}

Aiano, Felicity ^{[1
]}

Amin-Chowdhury, Zahin ^{[1
]}

Letley, Louise ^{[1
]}

Flood, Jessica ^{[1
]}

Jones, Samuel E. I. ^{[1
]}

Kall, Meaghan ^{[1
]}

Borrow, Ray ^{[9
]}

Linley, Ezra ^{[9
]}

Zambon, Maria ^{[1
]}

Poh, John ^{[1
]}

Lackenby, Angie ^{[1
]}

Ellis, Joanna ^{[1
]}

Amirthalingam, Gayatri ^{[1
]}

Brown, Kevin E. ^{[1
]}

Ramsay, Mary E. ^{[1
]}

机构：

[1] Natl Infect Serv, Publ Hlth England, 61 Colindale Ave, London NW9 5EQ, England

[2] St Georges Univ, Paediat Infect Dis Res Grp, London SW17 0RE, England

[3] East London NHS Fdn Trust, 9 Allie St, London E1 8DE, England

[4] Univ Hosp Derby, 201 London Rd, Derby DE1 2TZ, England

[5] Burton NHS Fdn Trust, 201 London Rd, Derby DE1 2TZ, England

[6] Univ Manchester, NHS Fdn Trust, Oxford Rd, Manchester M13 9WL, Lancs, England

[7] Birmingham Commun Hlthcare NHS Trust, Holt St, Aston B7 4BN, England

[8] Oxford Univ Hosp, NHS Fdn Trust, Old Rd, Oxford OX3 7HE, England

[9] Univ Oxford, Nuffield Dept Med, Wellington Sq, Oxford OX1 2JD, England

来源：

ECLINICALMEDICINE | 2021年 / 37卷

关键词：

COVID-19;

D O I：

10.1016/j.eclinm.2021.100948

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Older children have higher SARS-CoV-2 infection rates than younger children. We investigated SARS-CoV-2 infection, seroprevalence and seroconversion rates in staff and students following the full reopening of all secondary schools in England. Methods: Public Health England (PHE) invited secondary schools in six regions (East and West London, Hertfordshire, Derbyshire, Manchester and Birmingham) to participate in SARS-CoV-2 surveillance during the 2020/21 academic year. Participants had nasal swabs for RT-PCR and blood samples for SARS-CoV-2 antibodies at the beginning (September 2020) and end (December 2020) of the autumn term. Multivariable logistic regression was used to assess independent risk factors for seropositivity and seroconversion. Findings: Eighteen schools in six regions enrolled 2209 participants, including 1,189 (53.8%) students and 1,020 (46.2%) staff. SARS-CoV-2 infection rates were not significantly different between students and staff in round one (5/948; [0.5356] vs. 2/876 [0.23%]; p = 0.46) or round two (10/948 [1.05%] vs. 7/886 [0.79%]; p = 0.63), and similar to national prevalence. None of four and 7/15 (47%) sequenced strains in rounds 1 and 2 were the highly transmissible SARS-CoV-2 B.1.1.7 variant. In round 1, antibody seropositivity was higher in students than staff (114/893 [12.8%] vs. 79/861 [9.2%]; p = 0.016), but similar in round 2 (117/893 [13.1%] vs.117/872 [13.3%]; p = 0.85), comparable to local community seroprevalence. Between the two rounds, 8.7% (57/652) staff and 6.6% (36/549) students seroconverted (p = 0.16). Interpretation: In secondary schools, SARS-CoV-2 infection, seropositivity and seroconversion rates were similar in staff and students, and comparable to local community rates. Ongoing surveillance will be important for monitoring the impact of new variants in educational settings. Crown Copyright (C) 2021 Published by Elsevier Ltd.

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