Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine

被引：32

作者：

Carbone, Michele ^{[1
]}

Amelio, Ivano ^{[2
]}

Affar, El Bachir ^{[3
]}

Brugarolas, James ^{[4
]}

Cannon-Albright, Lisa A. ^{[5
,6
]}

Cantley, Lewis C. ^{[7
]}

Cavenee, Webster K. ^{[8
]}

Chen, Zhijian ^{[9
,10
]}

Croce, Carlo M. ^{[11
]}

D'Andrea, Alan ^{[12
]}

Gandara, David ^{[13
]}

Giorgi, Carlotta ^{[14
]}

Jia, Wei ^{[1
]}

Lan, Qing ^{[15
]}

Mak, Tak Wah ^{[16
]}

Manley, James L. ^{[17
]}

Mikoshiba, Katsuhiko ^{[18
]}

Onuchic, Jose N. ^{[19
]}

Pass, Harvey I. ^{[20
]}

Pinton, Paolo ^{[14
]}

Prives, Carol ^{[21
]}

Rothman, Nathaniel ^{[15
]}

Sebti, Said M. ^{[22
,23
]}

Turkson, James ^{[1
]}

Wu, Xifeng ^{[24
]}

Yang, Haining ^{[1
]}

Yu, Herbert ^{[1
]}

Melino, Gerry ^{[2
,25
]}

机构：

[1] Hawaii Canc Ctr, Honolulu, HI 96813 USA

[2] MRC Toxicol Unit, Leicester, Leics, England

[3] Univ Montreal, Maisonneuve Rosemont Hosp, Dept Med, Res Ctr, Montreal, PQ H1T 2M4, Canada

[4] Univ Texas Southwestern Med Ctr Dallas, Hematol Oncol Div, Dept Internal Med, Kidney Canc Program,Simmons Comprehens Canc Ctr, Dallas, TX 75390 USA

[5] Univ Utah, Dept Internal Med, Huntsman Canc Inst, Genet Epidemiol,Sch Med, Salt Lake City, UT 84112 USA

[6] George E Wahlen Dept Vet Affairs Med Ctr, Salt Lake City, UT 84148 USA

[7] Weill Cornell Med Coll, Meyer Canc Ctr, 413 E 69th St, New York, NY 10021 USA

[8] Univ Calif San Diego, Ludwig Inst Canc Res, La Jolla, CA 92093 USA

[9] Univ Texas Southwestern Med Ctr Dallas, Dept Mol Biol, Dallas, TX 75390 USA

[10] Univ Texas Southwestern Med Ctr Dallas, Howard Hughes Med Inst, Dallas, TX 75390 USA

[11] Ohio State Univ, Comprehens Canc Ctr, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA

[12] Harvard Med Sch, Dana Farber Canc Inst, Dept Radiat Oncol, Boston, MA 02215 USA

[13] Univ Calif Davis, Thorac Oncol, Sacramento, CA 96817 USA

[14] Univ Ferrara, Sect Pathol Oncol & Expt Biol, Dept Morphol Surg & Expt Med, Lab Technol Adv Therapies LTTA, Ferrara, Italy

[15] NCI, Occupat & Environm Epidemiol Branch, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA

[16] Princess Margaret Canc Ctr, Campbell Family Inst Breast Canc Res, Toronto, ON M5G 2M9, Canada

[17] Columbia Univ, Dept Biol Sci, New York, NY 10027 USA

[18] RIKEN, Brain Sci Inst, Lab Dev Neurobiol, Wako, Saitama 3510198, Japan

[19] Rice Univ, Ctr Theoret Biol Phys, Houston, TX 77005 USA

[20] NYU, Dept Cardiothorac Surg, Div Gen Thorac Surg, Langone Med Ctr, New York, NY USA

[21] Columbia Univ, Dept Biol Sci, New York, NY 10027 USA

[22] Univ S Florida, Drug Discovery Dept, Moffitt Canc Ctr, Tampa, FL 33612 USA

[23] Univ S Florida, Dept Oncol Sci, Tampa, FL 33612 USA

[24] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[25] Univ Roma Tor Vergata, Dept Expt Med & Surg, Rome, Italy

来源：

CELL DEATH AND DIFFERENTIATION | 2018年 / 25卷 / 11期

关键词：

INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; GERMLINE BAP1 MUTATIONS; CELL LUNG-CANCER; ACUTE MYELOID-LEUKEMIA; CHRONIC LYMPHOCYTIC-LEUKEMIA; MITOCHONDRIAL CALCIUM UNIPORTER; STRAND BREAK REPAIR; MUTANT P53; MALIGNANT MESOTHELIOMA; ENDOPLASMIC-RETICULUM;

D O I：

10.1038/s41418-018-0213-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The relative contribution of intrinsic genetic factors and extrinsic environmental ones to cancer aetiology and natural history is a lengthy and debated issue. Gene-environment interactions (G x E) arise when the combined presence of both a germline genetic variant and a known environmental factor modulates the risk of disease more than either one alone. A panel of experts discussed our current understanding of cancer aetiology, known examples of G x E interactions in cancer, and the expanded concept of G x E interactions to include somatic cancer mutations and iatrogenic environmental factors such as anti-cancer treatment. Specific genetic polymorphisms and genetic mutations increase susceptibility to certain carcinogens and may be targeted in the near future for prevention and treatment of cancer patients with novel molecularly based therapies. There was general consensus that a better understanding of the complexity and numerosity of G x E interactions, supported by adequate technological, epidemiological, modelling and statistical resources, will further promote our understanding of cancer and lead to novel preventive and therapeutic approaches.

引用

页码：1885 / 1904

页数：20

共 219 条

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