In Vivo Function of the ER-Golgi Transport Protein LMAN1 in Photoreceptor Homeostasis

被引：3

作者：

Hao, Hong ^{[1
]}

Gregorski, Janina ^{[2
]}

Qian, Haohua ^{[3
]}

Li, Yichao ^{[3
]}

Gao, Chun Y. ^{[4
]}

Idrees, Sana ^{[5
]}

Zhang, Bin ^{[6
]}

机构：

[1] NEI, Neurobiol Neurodegenerat & Repair Lab, NIH, Bethesda, MD 20892 USA

[2] New York Med Coll, Grad Sch Basic Med Sci, Valhalla, NY 10595 USA

[3] NEI, Visual Funct Core, Bethesda, MD 20892 USA

[4] NEI, Biol Imaging Core Facil, Bethesda, MD 20892 USA

[5] George Washington Univ, Sch Med, Washington, DC 20037 USA

[6] Cleveland Clin Fdn, Lerner Res Inst, Genom Med Inst, Cleveland, OH 44195 USA

来源：

RETINAL DEGENERATIVE DISEASES: MECHANISMS AND EXPERIMENTAL THERAPY | 2014年 / 801卷

关键词：

LMAN1; NRL; Photoreceptor; Transport; Homeostasis; COMPLEX; GM130;

D O I：

10.1007/978-1-4614-3209-8_50

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

LMAN1 is a type I transmembrane protein that selectively transports its cargo proteins from ER to ER-Golgi intermediate compartment (ERGIC) and Golgi. Lman1 is a direct target of the transcription factor NRL in mouse retina. Therefore, we examined the in vivo function of LMAN1 in retina. Although Lman1(-/-) mouse eyes did not show abnormality in histology and electroretinogram analysis at 3 months, Lman1(-/-) retina at 6 months showed a decrease in cis-Golgi markers GM130 and GRASP65. We also observed abnormal level and location of Rhodopsin in these mice. Taken together, LMAN1 may play a role in photoreceptor gene transport and homeostasis.

引用

页码：395 / 399

页数：5

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