Methamphetamine induces oligodendroglial cell death in vitro

被引：25

作者：

Genc, K ^{[1
]}

Genc, S

Kizildag, S

Sonmez, U

Yilmaz, O

Tugyan, K

Ergur, B

Sonmez, A

Buldan, Z

机构：

[1] Dokuz Eylul Univ, Dept Physiol, TR-35340 Izmir, Turkey

[2] Dokuz Eylul Univ, Dept Med Biol & Genet, TR-35340 Izmir, Turkey

[3] Dokuz Eylul Univ, Dept Histol & Embryol, TR-35340 Izmir, Turkey

[4] Dokuz Eylul Univ, Ctr Anim Res, TR-35340 Izmir, Turkey

来源：

BRAIN RESEARCH | 2003年 / 982卷 / 01期

关键词：

methamphetamine; oligodendrocyte; apoptosis; rat;

D O I：

10.1016/S0006-8993(03)02890-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated whether the psychostimulant methamphetamine (METH) has a cytotoxic effect on oligodendrocytes and which cell-death pathways are involved in the cytotoxic process. METH caused concentration- and time-dependent cytotoxicity in rat oligodendrocyte cultures. METH induced apoptotic cell death and mRNA expression of pro-apoptotic proteins (bax and DP5), but not anti-apoptotic proteins (bcl-2 and bcl-XL). These results suggest that METH induces cytotoxicity in rat oligodendrocytes via the differential regulation of the expression of genes involved in the apoptotic process. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：125 / 130

页数：6

共 18 条

[1] Glial cells as targets for cytotoxic immune mediators [J].