Enantiomeric separation of five acidic drugs via capillary electrophoresis using streptomycin as chiral selector

被引：15

作者：

Zhang, Xuejiao ^{[1
,2
]}

Qi, Shuhua ^{[1
]}

Liu, Chunye ^{[2
]}

Zhao, Xiaoli ^{[1
]}

机构：

[1] Northwestern Polytech Univ, Sch Sci, Dept Appl Chem, Xian 710129, Shaanxi, Peoples R China

[2] Xian Med Univ, Dept Pharm, Xian 710021, Shaanxi, Peoples R China

来源：

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2017年 / 1063卷

基金：

中国国家自然科学基金;

关键词：

Capillary electrophoresis; Enantioseparation separation; Acidic drugs; Streptomycin; BASIC DRUGS; CLINDAMYCIN PHOSPHATE; LACTOBIONATE; RESOLUTION;

D O I：

10.1016/j.jchromb.2017.08.014

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A simple capillary zone electrophoresis (CZE) method was developed to achieve the rapid enantiomeric separation of a set of acidic drugs using streptomycin as chiral selector. The enantiomers of 5 chiral phenyl containing acidic pharmaceutical compounds were separated excellently by CE using an uncoated silica capillary. Several experimental parameters such as the concentration of streptomycin, buffer concentration and pH, running voltage, and capillary temperature were all investigated systematically in order to optimize the chiral separation. All analytes were got baseline separation within 10 min. And the results showed that streptomycin can be used as a chiral selector to the enantioseparation of five acidic drugs by CZE method.

引用

页码：31 / 35

页数：5

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