Impact of HIV co-infection on immunological biomarker profile of HTLV-1 infected patients

被引：1

作者：

Borges Starling, Ana Lucia ^{[1
,2
]}

Souza Pereira, Silvio Roberto ^{[2
]}

Peruhype-Magalhaes, Vanessa ^{[1
]}

Alves Coelho-dos-Reis, Jordana Grazziela ^{[1
,3
]}

Bicalho, Kelly Alves ^{[1
]}

de Paiva, Luciene Pimenta ^{[1
]}

Martins, Julia Pereira ^{[1
]}

Trindade, Bruno Caetano ^{[1
]}

Labanca, Ludimila ^{[4
]}

Faccioli, Lucia Helena ^{[5
]}

Lambertucci, Jose Roberto ^{[4
]}

dos Santos Silva, Luciana Cristina ^{[4
]}

de Figueiredo Antunes, Carlos Mauricio ^{[4
]}

Teixeira-Carvalho, Andrea ^{[1
]}

de Freitas Carneiro-Proietti, Anna Barbara ^{[6
]}

Goncalves, Denise Ustch ^{[4
]}

Martins-Filho, Olindo Assis ^{[1
]}

机构：

[1] FIOCRUZ Minas, Inst Rene Rachou, Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Hosp Clin, Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais, Inst Ciencias Biol, Belo Horizonte, MG, Brazil

[4] Univ Fed Minas Gerais, Fac Med, Belo Horizonte, MG, Brazil

[5] Univ Sao Paulo, Fac Farm, Ribeirao Preto, SP, Brazil

[6] Fundacao HEMOMINAS, Ribeirao Preto, Brazil

来源：

IMMUNOLOGY LETTERS | 2021年 / 236卷

关键词：

Chemokines; Leukotrienes; Cytokines; Biomarkers; HTLV-1/HIV co infection; HTLV-1; VIRUS TYPE-I; MYELOPATHY/TROPICAL SPASTIC PARAPARESIS; NECROSIS-FACTOR-ALPHA; T-CELLS; PERIPHERAL-BLOOD; PROVIRAL LOAD; PROINFLAMMATORY CHEMOKINES; DRUG-USERS; CD4(+); SERUM;

D O I：

10.1016/j.imlet.2021.05.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The impact of HIV co-infection on the plasma immunological biomarker profile of HTLV-1 infected patients was evaluated. The plasma levels of leukotrienes and chemokines/cytokines were quantified by ELISA and Cytometric Bead Array. A total of 138 volunteers were enrolled and divided into two subgroups ("HTLV-1(+)HIV(-)" and "HTLV-1(+)(HIV(+)"), which were categorized according to the HTLV-1-associated neurological disease (AS, pHAM and HAM). Reference controls were BD and HIV mono-infected patients. HAM(+) exhibited higher CD4(+) T-cell counts as compared to HIV+ mono-infected patients and lower HTLV-1 proviral load as compared to mono-infected HAM(-) patients. AS(+) exhibited higher levels of CysLT, CXCL8/IL-8 and lower levels of CCL5/ RANTES as compared to AS(-). Increased levels of IL-6 and TNF with reduced levels of CXCL10/IP10 and CCL5/ RANTES were observed in co-infected pHAM(+) as compared to mono-infected pHAM(-). HAM(+) patients revealed an increase in CXCL8/IL-8, CCL2/MCP-1, CXCL-10/IP-10, TNF and a decrease in IL-2 as compared to HAM(-) subgroup.

引用

页码：68 / 77

页数：10

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