Dynamics of dopamine and norepinephrine contents in the dorsal hippocampus of rats during immunization with dopamine conjugate

被引：1

作者：

Umriukhin, A. E. ^{[1
]}

Diukareva, E. V.

Vetrile, L. A.

Trekova, N. A.

Kravtsov, A. N.

Evseev, V. A.

Sudakov, K. V.

机构：

[1] Russian Acad Med Sci, PK Anokhin Normal Physiol Res Inst, Moscow 109801, Russia

[2] Russian Acad Med Sci, Inst Gen Pathol & Pathophysiol, Moscow 109801, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2007年 / 143卷 / 04期

基金：

俄罗斯基础研究基金会;

关键词：

stress; behavior; immunization; dopamine; norepinephrine; microdialysis;

D O I：

10.1007/s10517-007-0140-9

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The dynamics of dopamine and norepinephrine contents in the dorsal hippocampus of rats immunized with a dopamine-BSA conjugate was studied during immobilization stress by mean of the microdialysis technique. Immunization with dopamine conjugate was accompanied by intensive production of antibodies against dopamine in rat blood and a tendency toward an increase in dopamine content in the dorsal hippocampus even in the basal state (before stress exposure). Under stress conditions, dopamine content in the dorsal hippocampus of immunized rats significantly increased. In control rats, stress was accompanied by a significant increase in norepinephrine content in the dorsal hippocampus. The observed peculiarities in dopamine and norepinephrine contents in the dorsal hippocampus of rats immunized with a dopamine conjugate were typical of active animals more resistant to emotional stress.

引用

页码：399 / 402

页数：4

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