Efficacy of folic acid in children with migraine, hyperhomocysteinemia and MTHFR polymorphisms

被引：32
作者：
Di Rosa, Gabriella
Attina, Sarina
Spano, Maria
Ingegneri, Giulia
Sgro, Domenica L.
Pustorino, Giuseppina
Bonsignore, Maria
Trapani-Lombardo, Vincenzo
Tortorella, Gaetano
机构：
[1] Univ Hosp, Dept Med & Surg Pediat, Unit Infantil Neuropsychiat, I-98125 Messina, Italy
[2] Melacrino Morelli Hosp Reggio Calabria, Hematol Unit, Reggio Di Calabria, Italy
来源：
HEADACHE | 2007年 / 47卷 / 09期
关键词：
migraine; homocysteine; MTHFR; folic acid; children;
D O I：
10.1111/j.1526-4610.2007.00932.x
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
MTHFR gene variants C677T and A1298C seem to be related to an increased risk of migraine. Folates' metabolism could play a role in the pathophysiology of migraine. We supplemented 16 children with migraine, hyperhomocysteinemia, and MTHFR polymorphisms with folic acid and obtained a resolution/reduction of migraine attacks. Although the mechanism leading to these effects has been not made clear, we believe that the use of folic acid needs further investigations in migraineurs with hyperhomocysteinemia and MTHFR variants. A randomized, double-blind, placebo controlled crossover trial is needed to support these findings.
引用
收藏
页码：1342 / 1344
页数：3
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