Calcium concentration in hypoxic-ischemic encephalopathy during hypothermia

被引：5

作者：

Yamamoto, Yutaka ^{[1
,2
,3
]}

Ibara, Satoshi ^{[3
]}

Tokuhisa, Takuya ^{[3
,5
]}

Hirakawa, Eiji ^{[3
]}

Yoneda, Satoshi ^{[3
,6
]}

Kobayashi, Kosuke ^{[3
,7
]}

Kato, Eiji ^{[3
,8
]}

Maruyama, Yuko ^{[3
,4
]}

Maede, Yoshinobu ^{[3
]}

Kuwabara, Takako ^{[3
]}

机构：

[1] Gifu Prefectural Gen Med Ctr, Dept Neonatol, Gifu 5008717, Japan

[2] Gifu Univ, Grad Sch Med, Dept Pediat, Gifu, Japan

[3] Kagoshima City Hosp, Perinatal Med Ctr, Kagoshima, Japan

[4] Imakiire Gen Hosp, Perinatal Ctr, Kagoshima, Japan

[5] Fukuda Hosp, Dept Neonatol, Kumamoto, Japan

[6] Toyama Univ, Dept Obstet & Gynecol, Toyama 930, Japan

[7] Asahi Cent Hosp, Dept Obstet & Gynecol, Chiba, Japan

[8] Funabashi Cent Hosp, Dept Neonatol, Chiba, Japan

来源：

PEDIATRICS INTERNATIONAL | 2015年 / 57卷 / 01期

关键词：

asphyxia; calcium; hypothermia; hypoxia-ischemia; newborn; IONIZED CALCIUM; TERM INFANTS; NEONATAL ENCEPHALOPATHY; BB ISOENZYME; BRAIN; BLOOD; SERUM; ASPHYXIA; DAMAGE; DEATH;

D O I：

10.1111/ped.12438

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

BackgroundThe aim of this study was to investigate the relationship between prognosis and the changes in serum-ionized calcium concentration in neonates with hypoxic-ischemic encephalopathy (HIE) before and during brain hypothermia (BHT). MethodsSerum samples were obtained from 16 HIE neonates who underwent BHT. All patients underwent developmental testing at 18 months of age. ResultsMean serum-ionized calcium concentration in the poor outcome group (developmental quotient [DQ], <80; nine infants) was significantly lower than in the good outcome group (DQ >80; seven infants), both immediately before and after 6h of BHT. Mean serum-ionized calcium concentration significantly decreased in both groups for 6h, and the lowest adjusted serum-ionized calcium during 6h of BHT was <1.05mmol/L, known as the cut-off value for poor outcome, in 57.1% of the good outcome group. ConclusionThe influx of calcium into cells continues regardless of neurological prognosis during the early phase of BHT, but BHT might protect some high-risk patients against neurological damage at low adjusted serum-ionized calcium concentration.

引用

页码：64 / 67

页数：4

共 23 条

[1]

Avery GB, 2005, CALCIUM MAGNESIUM HO, P847

[2] Moderate Hypothermia to Treat Perinatal Asphyxial Encephalopathy. [J].

Azzopardi, Denis V. ;

Strohm, Brenda ;

Edwards, A. David ;

Dyet, Leigh ;

Halliday, Henry L. ;

Juszczak, Edmund ;

Kapellou, Olga ;

Levene, Malcolm ;

Marlow, Neil ;

Porter, Emma ;

Thoresen, Marianne ;

Whitelaw, Andrew ;

Brocklehurst, Peter .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (14) :1349-1358

[3] CAUSES OF CALCIUM-ACCUMULATION IN RAT CORTICAL BRAIN-SLICES DURING HYPOXIA AND ISCHEMIA - ROLE OF ION CHANNELS AND MEMBRANE DAMAGE [J].

BICKLER, PE ;

HANSEN, BM .

BRAIN RESEARCH, 1994, 665 (02) :269-276

[4] SERUM CPK-BB ISOENZYME IN THE ASSESSMENT OF BRAIN-DAMAGE IN ASPHYCTIC TERM INFANTS [J].

FERNANDEZ, F ;

VERDU, A ;

QUERO, J ;

PEREZHIGUERAS, A .

ACTA PAEDIATRICA SCANDINAVICA, 1987, 76 (06) :914-918

[5]

GARCIAALIX A, 1994, PEDIATRICS, V93, P234

[6] Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial [J].

Gluckman, PD ;

Wyatt, JS ;

Azzopardi, D ;

Ballard, R ;

Edwards, AD ;

Ferriero, DM ;

Polin, RA ;

Robertson, CM ;

Thoresen, M ;

Whitelaw, A ;

Gunn, AJ .

LANCET, 2005, 365 (9460) :663-670

[7]

Gomella T.L., 2013, Neonatology: Management, procedures, on-call problems, diseases, and drugs

[8] Cooling for newborns with hypoxic ischaemic encephalopathy [J].

Jacobs, Susan E. ;

Berg, Marie ;

Hunt, Rod ;

Tarnow-Mordi, William O. ;

Inder, Terrie E. ;

Davis, Peter G. .

COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2013, (01)

[9] Delayed hypothermia as selective head cooling or whole body cooling does not protect brain or body in newborn pig subjected to hypoxia-ischemia [J].

Karlsson, Mathias ;

Tooley, James R. ;

Satas, Saulius ;

Hobbs, Catherine E. ;

Chakkarapani, Ela ;

Stone, Janet ;

Porter, Helen ;

Thoresen, Marianne .

PEDIATRIC RESEARCH, 2008, 64 (01) :74-80

[10] Changes of lactate, glucose, ionized calcium and glutamate concentrations in cephalic vein blood during brain hypothermia using extracorporeal membrane oxygenation (ECMO) in a newborn infant with hypoxic-ischemic encephalopathy [J].

Kobayashi, K ;

Ibara, S ;

Kusumoto, M ;

Maruyama, H ;

Kato, E ;

Maruyama, Y .

JOURNAL OF PERINATAL MEDICINE, 2005, 33 (04) :360-363

← 1 2 3 →