Building libraries of skeletally diverse scaffolds from novel heterocyclic active methylene compound through multi-component reactions

被引：12

作者：

Jayarajan, Ramasamy ^{[1
]}

Vasuki, Gnanasambandam ^{[1
]}

机构：

[1] Pondicherry Univ, Dept Chem, Pondicherry 605014, India

来源：

TETRAHEDRON LETTERS | 2012年 / 53卷 / 24期

关键词：

Novel heterocyclic active methylene compound; Diversity oriented synthesis; Multi-component reaction; Polycyclic heterocycles; Spiro heterocyclic scaffold; ONE-POT SYNTHESIS; ORIENTED SYNTHESIS; SPIROOXINDOLE DERIVATIVES; EFFICIENT SYNTHESIS; WATER; NAPHTHOPYRAN; STRATEGY;

D O I：

10.1016/j.tetlet.2012.04.013

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Libraries of skeletally diverse potential bioactive polycyclic/spirocyclic heterocyclic compounds: 2-amino-7, 9-dimethyl-5-oxo-4-aryl-4,5,6,7-tetrahydropyrano[2,3-d]pyrazolo[3,4-b]pyridine-3-carbonitrile, 2'-amino-7',9'-dimethyl-2,5'-dioxo-6',7'-dihydro-5'H-spirorindoline-3,4'-pyrano[2,3-d]pyrazolo[3,4-blpyridine]-3'-carbonitrile, and 5,5'-(arylmethylene)bis(4-hydroxy-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6(7H)-one) have been synthesized through a multi-component reaction using novel heterocyclic active methylene compound 4-hydroxy-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridine-6(7H)-one as one of the building blocks. This protocol can be considered to be an efficient and eco-friendly strategy for diversity oriented synthesis. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：3044 / 3048

页数：5

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