Fish Tank Granuloma Caused by Mycobacterium marinum

被引：38

作者：

Wu, Ting-Shu ^{[1
,2
]}

Chiu, Cheng-Hsun ^{[3
]}

Yang, Chih-Hsun ^{[4
]}

Leu, Hsieh-Shong ^{[1
]}

Huang, Ching-Tai ^{[1
]}

Chen, Yi-Chieh ^{[5
]}

Wu, Tsu-Lan ^{[6
,7
]}

Chang, Pi-Yueh ^{[6
,7
,8
]}

Su, Lin-Hui ^{[6
,7
]}

Kuo, An-Jing ^{[6
,7
]}

Chia, Ju-Hsin ^{[6
,7
,8
]}

Lu, Chia-Chen ^{[9
]}

Lai, Hsin-Chih ^{[7
,8
,10
]}

机构：

[1] Chang Gung Univ, Div Infect Dis, Dept Internal Med, Chang Gung Mem Hosp,Coll Med, Tao Yuan, Taiwan

[2] Chang Gung Univ, Grad Inst Clin Med Sci, Tao Yuan, Taiwan

[3] Chang Gung Univ, Div Infect Dis, Dept Pediat,Coll Med, Chang Gung Childrens Hosp,Chang Gung Mem Hosp, Tao Yuan, Taiwan

[4] Chang Gung Mem Hosp, Dept Dermatol, Tao Yuan, Taiwan

[5] Chang Gung Univ, Dept Plast & Reconstruct Surg, Chang Gung Mem Hosp, Coll Med, Tao Yuan, Taiwan

[6] Chang Gung Univ, Dept Lab Med, Chang Gung Mem Hosp, Coll Med, Tao Yuan, Taiwan

[7] Chang Gung Univ, Dept Med Biotechnol & Lab Sci, Tao Yuan, Taiwan

[8] Chang Gung Univ, Grad Inst Med Biotechnol & Lab Sci, Tao Yuan, Taiwan

[9] Fu Jen Catholic Univ, Dept Resp Therapy, New Taipei, Taiwan

[10] Chang Gung Univ, Res Ctr Pathogen Bacteria, Tao Yuan, Taiwan

来源：

PLOS ONE | 2012年 / 7卷 / 07期

关键词：

INFECTIONS; SUSCEPTIBILITY; DIAGNOSIS; SKIN;

D O I：

10.1371/journal.pone.0041296

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Introduction: Mycobacterium marinum causes skin and soft tissue, bone and joint, and rare disseminated infections. In this study, we aimed to investigate the relationship between treatment outcome and antimicrobial susceptibility patterns. A total of 27 patients with M. marinum infections were enrolled. Methods: Data on clinical characteristics and therapeutic methods were collected and analyzed. We also determined the minimum inhibitory concentrations of 7 antibiotics against 30 isolates from these patients. Results: Twenty-seven patients received antimycobacterial agents with or without surgical debridement. Eighteen patients were cured, 8 failed to respond to treatment, and one was lost to follow-up. The duration of clarithromycin (147 vs. 28; p = 0.0297), and rifampicin (201 vs. 91; p = 0.0266) treatment in the cured patients was longer than that in the others. Surgical debridement was performed in 10 out of the 18 cured patients, and in 1 of another group (p = 0.0417). All the 30 isolates were susceptible to clarithromycin, amikacin, and linezolid; 29 (96.7%) were susceptible to ethambutol; 28 (93.3%) were susceptible to sulfamethoxazole; and 26 (86.7%) were susceptible to rifampicin. However, only 1 (3.3%) isolate was susceptible to doxycycline. Discussion: Early diagnosis of the infection and appropriate antimicrobial therapy with surgical debridement are the mainstays of successful treatment. Clarithromycin and rifampin are supposed to be more effective agents.

引用

页数：6